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Parasitic diseases and immunodeficiencies

Published online by Cambridge University Press:  08 June 2007

P. AMBROISE-THOMAS
P. AMBROISE-THOMAS
Affiliation:
Laboratoire Interactions Cellulaires Parasite-Hôte (ICPH), Faculté de Médecine, Université Joseph Fournier-Grenoble, E.R., CNRS 2014, 38043 Grenoble, France
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Abstract

In the last two decades, major immunodeficiency syndromes have strongly influenced medical parasitology. Some animal parasitoses, once unknown in human medicine, have become zoonotic and sometimes anthroponotic. In other cases, the clinical evolution of human parasitoses has been severely aggravated and/or modified in immunodeficient patients especially in toxoplasmosis, cryptosporidiosis, leishmaniasis, strongyloidiasis and scabies. The parasites implicated are varied (protozoa, helminths and even Acaridae) but have in common the capacity to reproduce in or on the human host. These immunodeficiency syndromes are often related to AIDS but other major immunodepressions, such as post-therapeutically in organ transplantation, may also be responsible and raise difficult problems for prevention. The immunological mechanisms involved are not always well understood. In addition, genetic predisposition factors, gradually becoming better-understood in parasites and man, complete and complicate our understanding of the immunological mechanisms.

Keywords

Opportunistic parasitosesimmunodeficienciesAIDSorgan transplants
Type
Research Article
Information
Parasitology , Volume 122 , Supplement S1 , March 2001 , pp. S65 - S71
Copyright
© 2002 Cambridge University Press

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