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Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice

Published online by Cambridge University Press:  19 April 2010

XIAOYUE LI ,
JILONG SHEN ,
ZHENGRONG ZHONG ,
JUN PENG ,
HUIQIN WEN ,
JING LI ,
QINGLI LUO  and
WEI WEI
XIAOYUE LI
Affiliation:
Institute of Clinical Pharmacology, Anhui Medical University Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
JILONG SHEN*
Affiliation:
Institute of Clinical Pharmacology, Anhui Medical University Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
ZHENGRONG ZHONG
Affiliation:
Institute of Clinical Pharmacology, Anhui Medical University Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
JUN PENG
Affiliation:
Department of Pathology, Anhui Medical University Hospital of An Qing, P R China
HUIQIN WEN
Affiliation:
Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
JING LI
Affiliation:
Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
QINGLI LUO
Affiliation:
Provincial Laboratory of Zoonoses, Anhui Medical University Key Laboratory of Microbiology and Parasitology Anhui, Anhui Medical University Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education of China, Hefei, P R China
WEI WEI
Affiliation:
Institute of Clinical Pharmacology, Anhui Medical University
*
*Corresponding author: Provincial Laboratory of Zoonoses, Anhui Medical University, No. 81, Meishan Road, Hefei, China. Tel/Fax: +86 551 5113863. E-mail: [email protected]
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Summary

Treatment of liver fibrosis associated with Schistosoma japonicum ova-induced granulomas remains a challenging proposition. Paeoniflorin (PAE, C23H28O11) has anti-inflammatory, anti-allergic, and immunoregulatory effects and it is commonly used in Chinese Herbal prescriptions to treat hepatic disorders. The present study was carried out to investigate the effects of PAE on hepatic fibrosis of mice infected with S. japonicum and to explore its possible mechanism. Upon pathological examination of PAE-treated mice, the size of egg granuloma, fibrosis scores, the concentration of IL-13 and hydroxyproline in liver were significantly reduced compared with the model mice. In the primary culture of hepatic stellate cells (HSCs), PAE inhibited IL-13-induced collagen synthesis. These results suggested that PAE might alleviate the hepatic granulomas and fibrosis caused by S. japonicum and the inhibitory effect of PAE on hepatic fibrosis might be associated with its ability to decrease the level of IL-13 and to interfere with the IL-13 signalling molecule in HSCs.

Keywords

paeoniflorinschistosomiasisliver fibrosishepatic stellate cellIL-13suppressor of cytokine signalling-1STAT6
Type
Research Article
Information
Parasitology , Volume 137 , Issue 8 , July 2010 , pp. 1213 - 1225
Copyright
Copyright © Cambridge University Press 2010

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