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P19: a female and tissue specifically expressed gene in Schistosoma mansoni, regulated by pairing with the male

Published online by Cambridge University Press:  05 December 2003

A. MICHEL ,
J. KNOBLOCH  and
W. KUNZ
A. MICHEL
Affiliation:
Institute for Genetics, Genetic Parasitology, 40225 Düsseldorf, Germany
J. KNOBLOCH
Affiliation:
Institute for Genetics, Genetic Parasitology, 40225 Düsseldorf, Germany
W. KUNZ
Affiliation:
Institute for Genetics, Genetic Parasitology, 40225 Düsseldorf, Germany
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Abstract

A female-specific sequence was isolated from a cDNA library of Schistosoma mansoni and further characterizedSequences reported here are available from DDBJ/EMBL/GenBank under the Accession number Z27402.. Expression of the corresponding gene (p19) depends on pairing with a male. In situ hybridization and immunohistology experiments revealed exclusive expression of the gene in the cells of the vitellarium, suggesting a function in egg formation. In addition, experimental evidence for cross-linking of the protein under oxidative conditions supports the assumption that the p19 gene may code for an egg-shell precursor protein.

Keywords

Schistosoma mansoniegg-shellmale-female interactionfemale-specific gene expressionpairing-dependent gene expression
Type
Research Article
Information
Parasitology , Volume 127 , Issue 6 , December 2003 , pp. 519 - 524
Copyright
2003 Cambridge University Press

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