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Nutritional aspects of Ascaris infection in young protein-deficient pigs

Published online by Cambridge University Press:  06 April 2009

E. Forsum ,
M. C. Nesheim  and
D. W. T. Crompton
E. Forsum
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, and Department of Animal Husbandry, The Swedish University of Agricultural Sciences, Uppsala
M. C. Nesheim
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, and Department of Animal Husbandry, The Swedish University of Agricultural Sciences, Uppsala
D. W. T. Crompton
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, and Department of Animal Husbandry, The Swedish University of Agricultural Sciences, Uppsala
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Summary

Experiments were carried out to investigate the effects of Ascaris suum infection on the growth, food intake, nitrogen and fat utilization and intestinal function of young pigs receiving diets low in protein. An infection procedure was developed which provided relatively uniform and heavy infections in pigs under study. Ascaris-infected pigs showed statistically significant reduction in growth rate and food intake compared to uninfected controls. The reduction in growth rate was observed after the A. suum were mature and eggs were observed in the faeces of pigs. The degree of growth retardation was significantly correlated with worm burden. Infected pigs showed no consistent reduction in nitrogen and total solids digestibility compared to controls but fat digestion was reduced. The infected pigs showed reduced nitrogen retention compared to uninfected controls. Ascaris-infected pigs had heavier intestinal tracts with increased size of the tunica muscularis. Lactase activity in mucosa from infected pigs was significantly lower than in controls, whereas no consistent effect was observed in mucosal sucrase and maltase activity. When Ascaris-infected pigs were given an oral lactose load, blood glucose levels rose less than in control pigs, suggesting that the infection resulted in impaired lactose tolerance.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 3 , December 1981 , pp. 497 - 512
Copyright
Copyright © Cambridge University Press 1981

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References

REFERENCES

Armitage, P. (1971). Statistical Methods in Medical Research, 2nd Ed.Oxford, London, Edinburgh and Melbourne: Blackwell Scientific Publications.Google Scholar
Bray, B. (1953). Nitrogen metabolism in West African Children. British Journal of Nutrition 7, 3–13.CrossRefGoogle ScholarPubMed
Brown, K. H., Gilman, R. H., Khatun, M. & Ahmed, Md. G. (1980). Absorption of macro-nutrients from a rice-vegetable diet before and after treatment of ascariasis in children. American Journal of Clinical Nutrition 33, 1975–82.CrossRefGoogle Scholar
Dahlqvist, A. (1964). Method for assay of intestinal disaccharidases. Analytical Biochemistry 7, 18–25.CrossRefGoogle ScholarPubMed
Eggum, B. O. (1973). A Study of Certain Factors Influencing Protein Utilization in Rats and Pigs, p. 36. Copenhagen: Landhusholdningsselskabets Forlag.Google Scholar
Freij, L., Meeuwisse, G. W., Berg, N. O., Wall, S., Gebre-Medhin, M. (1979). Ascariasis and malnutrition. A study in urban Ethiopian children. American Journal of Clinical Nutrition 32, 1545–53.CrossRefGoogle ScholarPubMed
Gupta, M. C., Mithal, S., Arara, K. L. & Tandon, B. N. (1977). Effects of periodic deworming on nutritional status of Ascaris-infected pre-school children receiving supplementary food. Lancet 3, 108–10.CrossRefGoogle Scholar
Lifshitz, F. (1980). Carbohydrate malabsorption. In Clinical Disorders in Pediatric Gastroenterology and Nutrition (ed. Lifshitz, F.), pp. 229–247. New York and Basel: Marcel Dekker Inc.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–75.CrossRefGoogle ScholarPubMed
Manners, M. J. & Stevens, J. A. (1972). Changes from birth to maturity in the pattern of distribution of lactase and sucrase activity in the mucosa of the small intestine of pigs. British Journal of Nutrition 28, 113–27.CrossRefGoogle ScholarPubMed
McCance, R. A. (1960). Severe undernutrition in growing and adult animals. 1. Production and general effects. British Journal of Nutrition 14, 59–73.CrossRefGoogle Scholar
Official Swedish Agricultural Methods of Analysis (1966). Kungliga Lantbruksstyrelsens Kungörelse, no. 15. Stockholm, Sweden: Svenska Reproduktionscentralen AB.Google Scholar
Pond, W. G. & Haupt, K. A. (1978). The Biology of the Pig. Ithaca and London: Cornell University Press.Google Scholar
Spindler, L. A. (1947). The effect of experimental infections with ascarids of the growth of pigs. Helminthological Society of Washington, Proceedings 14, 58–63.Google ScholarPubMed
Stephenson, L. A., Pond, W. G., Nesheim, M. C., Krook, L. P. & Crompton, D. W. T. (1980 a). Ascaris suum: nutrient absorption, growth, and intestinal pathology in young pigs experimentally infected with 15-day-old larvae. Experimental Parasitology 49, 15–25.CrossRefGoogle ScholarPubMed
Stephenson, L. S. (1980). The contribution of A. lumbricoides to malnutrition in children. Parasitology 81, 221–33.CrossRefGoogle Scholar
Stephenson, L. S., Crompton, D. W. T., Latham, M. C., Schulpen, T. W. J., Nesheim, M. C. & Jansen, A. A. J. (1980 b). Relationships between Ascaris infection and growth of malnourished pre-school children in Kenya. American Journal of Clinical Nutrition 33, 1165–72.CrossRefGoogle ScholarPubMed
Stephenson, L. S., Georgi, J. R. & Cleveland, D. J. (1977). Infection of weanling pigs with known numbers of Ascaris suum fourth stage larvae. Cornell Veterinarian 67, 92–102.Google ScholarPubMed
Stewart, T. B., Johnson, J. C. & Hale, O. M. (1972). Effects of pyrantel HCl and dietary protein on growing pigs infected in different sequences with Strongyloides ransomi, Ascaris suum, and Oesophagotstonium spp. Journal of Animal Science 35, 561–8.CrossRefGoogle ScholarPubMed
Teotia, S. P. S., Teotia, M., Kunwar, K. B. & Misra, S. S. (1969). Fat malabsorption in intestinal parasitic infections in children. Journal of the Indian Medical Association 53, 577–82.Google Scholar
Tripathy, K., Duque, E., Bolaños, O., Lotero, H. & Mayoral, L. (1972). Malabsorption syndrome in ascariasis. American Journal of Clinical Nutrition 25, 1276–81.CrossRefGoogle ScholarPubMed
Venkatachalam, P. S. & Patwardhan, V. N. (1953). The role of Ascaris lumbricoides in the nutrition of the host. Effect of ascariasis on digestion of protein. Transactions of the Royal Society of Tropical Medicine and Hygiene 47, 169–75.CrossRefGoogle ScholarPubMed
Willett, W. C., Kilama, W. L. & Kihama, C. M. (1979). Ascaris and growth rates: a randomized trial of treatment. American Journal of Public Health 69, 987–91.CrossRefGoogle Scholar