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Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants

Published online by Cambridge University Press:  06 April 2009

Max Murray  and
W. I. Morrison
Max Murray
Affiliation:
International Laboratory for Research on Animal Diseases (ILRAD) P.O. Box 30709, Nairobi, Kenya
W. I. Morrison
Affiliation:
International Laboratory for Research on Animal Diseases (ILRAD) P.O. Box 30709, Nairobi, Kenya
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Summary

Administration of the immunostimulants Corynebacterium parvum, Bacillus Calmette-Guérin (BCG) or Bordetella pertussis prior to, or at the same time as, challenge with Trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged with Trypanosoma brucei following pre-treatment with C. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock.

Type
Research Article
Information
Parasitology , Volume 79 , Issue 3 , December 1979 , pp. 349 - 366
Copyright
Copyright © Cambridge University Press 1979

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References

REFERENCES

Biozzi, G., Benacerraf, B., Grumbach, F., Halpern, B., Levaditi, J. & Rist, N. (1954). étude do l'activité granulopexique du systàme réticulo-endothélial au cours de l'infection tuberculeuse expérimentale de la souris. Annales de l'Institut Pasteur (Paris) 87, 291–300.Google Scholar
Bout, D., Dupas, H., Carlier, Y., Afchain, D. & Capron, M. A. (1977). High resistance induced by young live Bacillus Calmette-Guérin (BCG) to Schistosoma mansoni infection in mice. Annales d'Immunologie (Institut Pasteur) 128C, 811–16.Google Scholar
Brener, Z. & Cardoso, J. E. (1976). Nonspecific resistance against Trypanosoma cruzi enhanced by Corynebacterium parvum. Journal of Parasitology 62, 645–6.CrossRefGoogle ScholarPubMed
Brocklesby, D. W. & Purnell, R. E. (1977). Failure of BCG to protect calves against Babesia divergens infection. Nature, London 265, 343.CrossRefGoogle ScholarPubMed
Capron, M. A. & Lesoin, M. A. (1969). Rˇle protecteur du BCG dans la schistosomiase expérimentale. Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences (Paris) 269, 2110–12.Google Scholar
Civil, R. H., Warren, K. S. & Mahmoud, A. A. F. (1978). Conditions for Bacille Calmette-Guérin-induced resistance to infection with Schistosoma mansoni in mice. Journal of Infectious Diseases 137, 550–5.CrossRefGoogle ScholarPubMed
Clark, I. A., Allison, A. C. & Cox, F. E. G. (1976). Protection of mice against Babesia and Plasmodium with BCG. Nature, London 259, 309–11.CrossRefGoogle ScholarPubMed
Clark, I. A., Cox, F. E. G. & Allison, A. C. (1977 a). Protection of mice against Babesia spp. and Plasmodium spp. with killed Corynebacterium parvum. Parasitology 74, 9–18.CrossRefGoogle ScholarPubMed
Clark, I. A., Wills, E. J., Richmond, J. E. & Allison, A. C. (1977 b). Suppression of babesiosis in BCG-infected mice and its correlation with tumour inhibition. Infection and Immunity, 17, 430–8.CrossRefGoogle Scholar
Corsini, A. C., Clayton, C., Askonas, B. A. & Ogilvie, B. M. (1977). Suppressor cells and loss of B-cell potential in mice infected with Trypanosoma brucei. Clinical and Experimental Immunology 29, 122–31.Google ScholarPubMed
Cottrell, B. J., Playfair, J. H. L. & De Sousa, B. (1977). Plasmodium yoellii and Plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. Experimental Parasitology 43, 45–53.CrossRefGoogle Scholar
Desowitz, R. S. (1959). Studies on immunity and host-parasite relationships. I. The immunological response of resistant and susceptible breeds of cattle to trypanosomal challenge. Annals of Tropical Medicine and Parasitology 53, 293–313.CrossRefGoogle ScholarPubMed
Diener, E. & Feldmann, M. (1972). Relationship between antigen and antibody-induced suppression of immunity. Transplantation Reviews 8, 76–103.Google ScholarPubMed
Doyle, J. J. (1977). Antigenic variation in the salivarian trypanosomes. In Immunity To Blood Parasites of Animals and Man, (ed. Miller, L. H., Pino, J. A. and McKelvey, J. J. Jr). Advances in Experimental Medicine and Biology, vol. 93, pp. 31–63. New York: Plenum Press.CrossRefGoogle Scholar
Dresser, D. W. & Phillips, J. M. (1973). The cellular targets for the action of adjuvants: T-adjuvants and B-adjuvants. In Immunopotentiation: Ciba Fdn Symp. 18, (ed. Knight, J. and Wolstenholme, G. E. H.), pp. 3–28. Amsterdam: Elsevier.Google Scholar
Fauve, R. M. & Dodin, A. (1976). Influence d'une réaction inflammatoire provoquée par le BCG ou par un irritant non biodégradable sur la résistance des souris à, la bilharziose. Comptes Rendus Hebdomadaires des Séances de l'Académie des sciences (Paris) 282, 131–4.Google Scholar
First Fao Expert Consultation On Research On Trypanotolerance And Breeding Of Trypanotolerant Animals (1976). Food and Agricultural Organization of the United Nations.Google Scholar
Florentin, J., Huchet, R., Bruley-Rosset, M., Halle-Pannenko, O. & Mathé, G. (1976). Studies on the mechanisms of action of BCG. Cancer Immunology and Immunotherapy 1, 31–9.Google Scholar
Freeman, T., Smithers, S. R., Targett, G. A. T. & Walker, P. J. (1970). Specificity of immunoglobulin G in rhesus monkeys infected with Schistosoma mansoni, Plasmodium knowlesi and Trypanosoma brucei. Journal of Infectious Diseases 121, 401–6.CrossRefGoogle ScholarPubMed
Gorczynski, R., Kontiainen, S., Mitchison, N. A. & Tigelaar, R. E. (1974). Antigen–antibody complexes as blocking factors on the T lymphocyte surface. In Cellular Selection and Regulation in the Immune Response (ed. Edelman, G. M.), pp. 143–54. New York: Raven Press.Google Scholar
Grove, D. I. & Civil, R. H. (1978). Trichinella spiralis: effects on the host–parasite relationship in mice of BCG (attenuated Mycobacterium bovis). Experimental Parasitology 44, 181–9.CrossRefGoogle ScholarPubMed
Halpern, B. N., Prévot, A. R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y. & Decreusefond, C. (1963). Stimulation de l'activité phagocytaire du système réticuloendothélial provoquée par Corynebacterium parvum. Journal of the Reticuloendothelial Society 1, 77–96.Google Scholar
Herman, R. & Baron, S. (1971). Immunologic-mediated protection of Trypanosoma congolense-infected mice by polyribonucleotides. Journal of Protozoology 18, 661–6.CrossRefGoogle ScholarPubMed
Hoff, R. (1975). Killing in vitro of trypanosoma cruzi by macrophages from mice immunised with T. cruzi or BCG and absence of cross immunity on challenge in vivo. Journal of Experimental Medicine 142, 299–311.CrossRefGoogle Scholar
Howard, J. G., Scott, M. T. & Christie, G. H. (1973). Cellular mechanisms underlying the adjuvant activity of Corynebacterium parvum: interaction of activated macrophages with T and B lymphocytes. In Immunopotentiation Ciba Fdn Symp. 18, (ed. Knight, J. and Wolstenholme, G. E. H.), pp. 101–14. Amsterdam: Elsevier.Google Scholar
Hudson, K. M., Byner, C., Freeman, J. & Terry, R. J. (1976). Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis. Nature, London 264, 256–8.CrossRefGoogle ScholarPubMed
Kierszenbaum, F. (1975). Enhancement of resistance and suppression of immunisation against experimental Trypanosoma cruzi infection by Corynebacterium parvum. Infection and Immunity 12, 1227–9.CrossRefGoogle ScholarPubMed
Kierszenbaum, F., Knecht, E., Budzko, D. B. & Pizzimenti, M. C. (1974). Phagocytosis: a defence mechanism against infection with Trypanosoma cruzi. Journal of Immunology 112, 1839–44.CrossRefGoogle ScholarPubMed
Kress, Y., Bloom, B. R., Wittner, M., Rowen, A. & Tanowitz, H. (1975). Resistance of Trypanosoma cruzi to killing by macrophages. Nature, London 257, 394–6.CrossRefGoogle ScholarPubMed
Lourie, E. M. & O'Connor, R. J. (1936). Trypanolysis in vitro by mouse immune serum. Annals of Tropical Medicine and Parasitology 30, 365–88.CrossRefGoogle Scholar
Luckins, A. G. (1972). Studies on bovine trypanosomiasis. Serum immunoglobulin levels in Zebu cattle exposed to natural infections in East Africa. British Veterinary Journal 128, 523–8.CrossRefGoogle ScholarPubMed
Mackaness, G. B., Lagrange, P. H. & Ishibashi, T. (1974). The modifying effect of BCG on the immunological induction of T cells. Journal of Experimental Medicine 139, 1540–52.CrossRefGoogle ScholarPubMed
Mattern, P., Masseyeff, R., Michel, R. & Peretti, P. (1961). étude immunochimique do la β2 macroglobuline des sérums de malades atteints de trypanosomiase africaine à T. gambiense. Annales de l'Institut Pasteur (Paris) 101, 382–8.Google Scholar
Morrison, W. I., Roelants, G. E., Mayor-Withey, K. S. & Murray, M. (1978). Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte population. Clinical and Experimental Immunology 32, 25–40.Google Scholar
Murray, M., Lambert, P. H. & Morrison, W. I. (1975). Renal lesions in experimental trypanosomiasis. In Les Glomérulonéphrites de la Zone Intertropicale. Médecine et Maladies Infectieuses. Leur Rapport avec les Endémies Parasitaires 12, 638–41.Google Scholar
Murray, M. & Urquhart, G. M. (1977). Immunoprophylaxis against African trypanosomiasis. In Immunity to Blood Parasites of Animals and Man (eds. Miller, L. H., Pino, J. A. and McKelvey, J. J. Jr,), Advances in Experimental Medicine and Biology, vol. 93, pp. 209–41. New York and London: Plenum Press.CrossRefGoogle Scholar
Murray, M., Morrison, W. I., Murray, P. K., Clifford, D. J. & Trail, J. C. M. (1979). Trypanotolerance. World Animal Review (in the Press).Google Scholar
Murray, P. K., Jennings, F. W., Murray, M. & Urquhart, G. M. (1974). Immunosuppression in trypanosomiasis. In Parasitic Zoonoses. Clinical and Experimental Studies, (ed. Soulsby, E. J. L.), pp. 133–50. New York, San Francisco and London: Academic Press.Google Scholar
Nussenzweig, R. S. (1967). Increased nonspecific resistance to malaria produced by administration of Corynebacterium parvum. Experimental Parasitology 21, 224–31.CrossRefGoogle Scholar
Olson, L. C. (1975). Pertussis. Medicine 54, 427–69.CrossRefGoogle ScholarPubMed
Ordal, J., Smith, S., Ness, P., Gershon, R. K. & Grumet, F. C. (1976). IgM-mediated, T cell-independent suppression of humoral immunity. Journal of Immunology 116, 1182–7.CrossRefGoogle ScholarPubMed
Ortiz-Ortiz, L., Gonzalez-Mendoza, A. & Lamoyi, E. (1975). A vaccination procedure against Trypanosoma cruzi in mice by nonspecific immunization. Journal of Immunology 114, 1424–5.CrossRefGoogle ScholarPubMed
Rau, M. E. & Tanner, C. E. (1975). BCG suppresses growth and metastasis of hydatid infections. Nature, London 256, 318–19.CrossRefGoogle ScholarPubMed
Singer, I., Kimble, E. T. & Ritts, R. E. (1964). Alterations of the host-parasite relationship by administration of endotoxin to mice with infection with trypanosomes. Journal of Infectious Diseases 114, 243–8.Google ScholarPubMed
Smrkovski, L. L. & Larson, C. L. (1977). Effect of treatment with BCG on the course of visceral leishmaniasis in BALB/c mice. Infection and Immunity 16, 249–57.CrossRefGoogle ScholarPubMed
Tabbara, K. F., O'Connor, G. R. & Nozik, R. A. (1975). Effect of immunisation with attenuated Mycobacterium bovis on experimental toxoplasmic retinochoroiditis. American Journal of Ophthalmology 79, 641–7.CrossRefGoogle ScholarPubMed
Thompson, R. C. A. (1976). Inhibitory effect of BCG on development of secondary hydatid cysts of Ecchinococcus granulosus. The Veterinary Record 99, 273.Google Scholar
Warr, G. W. & James, K. (1975). Effect of Corynebacterium parvum on the class and sub. class of antibody produced in the response of different strains of mice to sheep erythrocytes. Immunology 28, 431–2.Google Scholar
Weintraub, J. & Weinbaum, F. J. (1977). The effect of BCG on experimental cutaneous leishmaniasis in mice. Journal of Immunology 118, 2288–90.CrossRefGoogle ScholarPubMed