Hostname: page-component-7bb8b95d7b-2h6rp Total loading time: 0 Render date: 2024-09-13T20:51:05.664Z Has data issue: false hasContentIssue false
  • English
  • Français

Nippostrongylus brasiliensis: the distribution of primary worm populations within the small intestine of neonatal rats

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
D. Conwil Jenkins
Affiliation:
The Research Laboratories, May & Baker Ltd, Dagenham, Essex
Get access Rights & Permissions [Opens in a new window]

Extract

When neonatal rats were exposed to a small (200 larvae) primary infection of Nippostrongylus brasiliensis the worms that became established in the intestine were found in the mid-jejunum on both the seventh and the fourteenth day after infection. By day 21 most of the worms had migrated to the duodenum where they remained subsequently.

When similar rats were exposed to a heavy primary infection (1500 larvae) the worms were found to be distributed along the length of the duodenum and jejunum by the seventh day. By day 28, however, a proportion of worms equal to that formerly located in the jejunum had been expelled, leaving a population of about 300 worms in the duodenum.

It is suggested that the increased longevity of those worms that survive the effects of host immunity is dependent on their location at the duodenal site. The possibility is raised that the duodenum may be an immunologically privileged site for N. brasiliensis in young rats.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 3 , June 1974 , pp. 339 - 345
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Alphey, T. J. W., (1970). Studies on the distribution and site location of Nippostrongylus brasiliensis within the small intestine of laboratory rats. Parasitology 61, 449–60.CrossRefGoogle ScholarPubMed
Brambell, M. R., (1965). The distribution of a primary infestation of Nippostrongylus brasiliensis in the small intestine of laboratory rats. Parasitology 55, 313–24.CrossRefGoogle ScholarPubMed
Greenberg, Z., (1971). Passive transfer of immunity to Nippostrongylus brasiliensis (Travassos, 1914) from mother rats to offspring. Journal of Parasitology 57, 685–7.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H., & Urquhart, G. M., (1966). Irnrnunological unresponsiveness in adult rats to the nematode Nippostrongylus brasiliensis induced by infection in early life. Nature, London 211, 1310–1.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H., & Urquhart, G. M., (1968 a). Immunological unresponsiveness to helminth parasites. 1. The pattern of Nippostrongylus brasiliensis infections in young rats. Experimental Parasitology 23, 151–60.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H., & Urquhart, G. M., (1968 b). Immunological unresponsiveness in Nippostrongylus brasiliensis infection. In The Reaction of the Host to Parasitism (ed. Soulsby, E. J. L.,), pp. 242–9. N. G. Elwert Universitats und Verlagsbuchhandlung. Marburg/Lahn.Google Scholar
Jenkins, D. C., (1973). Observations on the distribution of an immune-adapted population of Nippostrongylus brasiliensis within the small intestine of rats given repeated small challenge infections. Zeitschrift für Parasitenkunde 41, 73–82.CrossRefGoogle Scholar
Jones, V. E., & Ogilvie, B. M., (1967). Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. III. Passive immunity in the young rat. International Archives of Allergy and Applied Immunology 31, 490–504.CrossRefGoogle Scholar
Kassai, T., & Aitken, I. D., (1967). Induction of immunological tolerance in rats to Nippostrongylus brasiliensis infection. Parasitology 57, 403–18.CrossRefGoogle ScholarPubMed
Keeling, J. E. D., (1960). The effects of ultra-violet radiation on Nippostrongylus muris 1. Irradiation of infective larvae: lethal and sublethal effects. Annals of Tropical Medicine and Parasitology 54, 182–91.CrossRefGoogle Scholar
Keller, R., & Keist, R., (1972). Protective immunity to Nippostrongylus brasiliensis in the rat: central role of the lymphocyte in worm expulsion. Immunology 22, 767–73.Google ScholarPubMed
Ogilvie, B. M., & Hockley, D. J., (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.Google Scholar
Ogilvie, B. M., & Jones, V. E., (1967). Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. 1. The effect of thymectomy, neonatal infections and splenectomy. Parasitology 57, 335–49.CrossRefGoogle Scholar
Ogilvie, B. M., & Jones, V. E., (1971). Nippostrongylus brasiliensis: a review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.CrossRefGoogle ScholarPubMed