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Nippostrongylus brasiliensis: observations on factors affecting the establishment of secondary worm populations in rats

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
D. Conwil Jenkins
Affiliation:
The Research Laboratories, May and Baker Ltd., Dagenham, Essex
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Extract

Previously immunized rats of different ages were exposed either to one large, or several small challenge infections with the nematode, Nippostrongylus brasiliensis. The number of secondary worms harboured by each of these rats was then determined on the fourteenth day after exposure to challenge. It was found that worms adapted more efficiently to host immunity when both (a) the rats were less than 11 weeks old when challenged and (b) the challenge was given in small repeated doses over a period of weeks. The age of the rats on exposure to the immunizing primary infection, however, had little or no affect per se on the subsequent establishment of immune-adapted worms. It is tentatively suggested that the failure of worms to adapt effectively to the acquired immunity of older rats resulted from the acquisition by these rats of a fully competent cellular immune response.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 1 , February 1974 , pp. 13 - 17
Copyright
Copyright © Cambridge University Press 1974

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References

Connan, R. M. (1972). The effect of host lactation on a second infection of Nippostrongylus brasiliensis in rats. Parasitology 64, 229–33.CrossRefGoogle ScholarPubMed
Dineen, J. K. & Kelly, J. D. (1972). The suppression of rejection of Nippostrongylus brasiliensis in lactating rats: the nature of the immunological defect. Immunology 22, 1–13.Google ScholarPubMed
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1966). Immunological unresponsiveness in adult rats to the nematode Nippostrongylus brasiliensis induced by infection in early life. Nature (London) 211, 1310–1.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1968 a). Immunological unresponsiveness to helminth parasites. 1. The pattern of Nippostrongylus brasiliensis infections in young rats. Experimental Parasitology 23, 151–60.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1968 b). Immunological unresponsiveness to Nippostrongylus brasiliensis infection. In The Reaction of the Host to Parasitism (ed. Soulsby, E. J. L.), pp. 242–9. Marburg/Lahn: N. G. Elwert Universitats und Verlagsbuchhandlung.Google Scholar
Jenkins, D. C. (1972). Nippostrongylus brasiliensis: observations on the comparative immunogenicity of adult worms from primary and immune-adapted infections. Parasitology 65, 547–50.CrossRefGoogle ScholarPubMed
Jenkins, D. C. & Phillipson, R. F. (1972 a). Increased establishment and longevity of Nippostrongylus brasiliensis in immune rats given repeated small infections. International Journal for Parasitology 2, 105–11.CrossRefGoogle ScholarPubMed
Jenkins, D. C. & Phillipson, R. F. (1972 b). Evidence that the nematode Nippostrongylus brasiliensis can adapt to and overcome the effects of host immunity. International Journal for Parasitology 2, 353–9.CrossRefGoogle ScholarPubMed
Kassai, T. & Aitken, I. D. (1967). Induction of immunological tolerance in rats to Nippostrongylus brasiliensis infection. Parasitology 57, 403–18.CrossRefGoogle ScholarPubMed
Keller, R. & Keist, R. (1972). Protective immunity to Nippostrongylus brasiliensis in the rat: central role of the lymphocyte in worm expulsion. Immunology 22, 767–73.Google ScholarPubMed
Ogilvie, B. M. & Hockley, D. J. (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.CrossRefGoogle ScholarPubMed
Ogilvie, B. M. & Jones, V. E. (1967). Reaginic antibodies and immunity to Nippostrongylus brasiliensis in the rat. 1. The effect of thymectomy, neonatal infections and splenectomy. Parasitology 57, 335–49.CrossRefGoogle Scholar
Ogilvie, B. M. & Jones, V. E. (1971). Nippostrongylus brasiliensis: a review of immunity and the host/parasite relationship in the rat. Experimental Parasitology 29, 138–77.CrossRefGoogle ScholarPubMed