Hostname: page-component-586b7cd67f-dsjbd Total loading time: 0 Render date: 2024-11-24T11:38:20.671Z Has data issue: false hasContentIssue false
  • English
  • Français

Nematodirus battus: scanning electron microscope studies of the duodenal mucosa of infected lambs

Published online by Cambridge University Press:  06 April 2009

Jean Martin  and
D. L. Lee
Jean Martin
Affiliation:
Department of Pure and Applied Zoology, University of Leeds, Leeds LS2 9JT
D. L. Lee
Affiliation:
Department of Pure and Applied Zoology, University of Leeds, Leeds LS2 9JT
Get access Rights & Permissions [Opens in a new window]

Summary

Lambs given 60000 third-stage larvae of Nematodirus battus were killed on days 16, 20, 22, 24 and 32 of the infection and the duodenal mucosa was examined by scanning electron microscopy (SEM). On day 16 of the infection the villi were long and finger-like and, although goblet cells were visible, the surface of the villi was not extensively folded, as is the surface of villi of uninfected control animals. By day 20 of the infection the villi had been reduced to flattened, plate-like structures or had formed low, irregular-shaped ridges. On this day of the infection the nematodes appeared to be enclosed by mucus-like material. As the infection progressed the intestinal damage was repaired, so that, by day 24 of the infection, the surface of the intestine was covered by short, smooth, finger-like projections and, by day 32 of the infection, the morphology of the intestine was somewhat similar to that of the control lamb. The possible role of villus atrophy and of mucus in the rejection of N. battus from the intestine is discussed.

Type
Research Article
Information
Parasitology , Volume 81 , Issue 3 , December 1980 , pp. 573 - 578
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Barker, I. K. (1973). Scanning electron microscopy of the duodenal mucosa of lambs infected with Trichostrongylus colubriformis. Parasitology 67, 307–14.Google Scholar
Coop, R. L., Angus, K. W. & Mapes, C. J. (1973). The effect of large doses of Nematodirus battus on the histology and biochemistry of the small intestine of lambs. International Journal for Parasitology 3, 349–61.Google Scholar
Ferguson, A. & Jarrett, E. E. E. (1975). Hypersensitivity reactions in the small intestine. 1. Thymus dependence of experimental ‘partial villous atrophy’. Gut 16, 114–17.Google Scholar
Lee, D. L. (1965). The cuticle of adult Nippostrongylus brasiliensis. Parasitology 55, 173–81.CrossRefGoogle ScholarPubMed
Lee, D. L. & Atkinson, H. J. (1976). Physiology of Nematodes, 2nd Edition, Macmillan Press.Google Scholar
Mapes, C. J. & Coop, R. L. (1972). The effect of single infections of Nematodirus battus in lambs. Parasitology 64, 197–216.Google Scholar
Martin, J. (1980). Scanning electron microscope studies of the small intestine of rats maintained on a low protein diet and infected with Nippostrongylus brasiliensis. Parasitology 80, 39–47.Google Scholar
Martin, J. & Lee, D. L. (1976). Observations on crystals found in the intestine of Nematodirus battus during the development of immunity to this nematode in lambs. Parasitology 72, 75–9.CrossRefGoogle ScholarPubMed
Miller, H. R. P. & Nawa, Y. (1979). Nippostrongylus brasiliensis: intestinal goblet cell response in adoptively immunised rats. Experimental Parasitology 47 (1), 81–90.CrossRefGoogle Scholar
Olson, L. J. & Richardson, J. A. (1968). Intestinal malabsorption of D-glucose in mice infected with Trichinella spiralis. Journal of Parasitology 54, 445–51.CrossRefGoogle ScholarPubMed
Pout, D. D. (1970). The mucosal surface patterns of the small intestine of grazing lambs. British Veterinary Journal 126, 257–63.CrossRefGoogle Scholar
Rowlands, D. T. & Probert, A. J. (1972). Some pathological changes in young lambs experimentally infected with Nematodirus battus. Research in Veterinary Science 13, 323–9.CrossRefGoogle ScholarPubMed
Symons, L. E. A. (1965). Kinetics of the epithelial cells and morphology of villi and crypts in the jejunum of the rat infected by the nematode Nippostrongylus brasiliensis. Gastro-enterology 49, 158–68.Google Scholar
Symons, L. E. A. (1976). Scanning electron microscopy of the jejunum of the rat infected by the nematodo Nippostrongylus brasiliensis. International Journal for Parasitology 6, 107–10.Google Scholar
Symons, L. E. A. & Fairbairn, D. (1963). Pathology of the rat jejunum parasitized by the nematode Nippostrongylus brasiliensis. Experimental Parasitology 13, 184–304.CrossRefGoogle ScholarPubMed
Symons, L. E. A. & Jones, W. O. (1970). Nematospiroides dubius, Nippostrongylus brasiliensis and Trichostrongylus colubriformis: protein digestion in infected mammals. Experimental Parasitology 27, 496–506.Google Scholar
Thomas, R. J. (1959). A comparative study of the life-histories of Nematodirus battus and N. filicollis nematode parasites of sheep. Parasitology 49, 374–86.Google Scholar
Wells, P. D. (1963). Mucin-secreting cells in rats infected with Nippostrongylus brasiliensis. Parasitology 14, 15–22.Google Scholar