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Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review

Published online by Cambridge University Press:  18 April 2022

Amanda Ponce Morais Cerqueira ,
Matheus da Cunha Santos ,
Manoelito Coelho dos Santos Júnior  and
Mariana Borges Botura Open the ORCID record for Mariana Borges Botura [Opens in a new window]
Amanda Ponce Morais Cerqueira
Affiliation:
Departamento de Biologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil
Matheus da Cunha Santos
Affiliation:
Departamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil
Manoelito Coelho dos Santos Júnior
Affiliation:
Departamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil
Mariana Borges Botura*
Affiliation:
Departamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil
*
Author for correspondence: Mariana Borges Botura, E-mail: [email protected]
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Abstract

The cattle tick Rhipicephalus microplus is an ectoparasite with high economic importance to bovine culture, mainly in tropical and subtropical regions. The resistance of the tick from the commercial acaricides has hindered its control, thus motivating the search for new strategies. The purpose of this study was to perform a critical review about the main molecular targets of R. microplus that are useful for the discovery of new acaricides. Bibliographic search was conducted in the databases PubMed, ScienceDirect and CAB Direct, using the following descriptors: ‘Rhipicephalus microplus’, ‘Boophilus microplus’, ‘molecular targets’ and ‘action’, published between 2010 and 2021. Out of the 212 publications identified, 17 articles were selected for study inclusion. This review described 14 molecular targets and among these 4 are targets from commercial acaricides. Most of them are enzymes to catalyse important reactions to tick survival, related to energetic metabolism, mechanisms of biotransformation and neurotransmission. The data will be helpful in the development of new more effective and selective acaricides.

Keywords

Acaricidesaction mechanismcattle tickenzymereceptor
Type
Review Article
Information
Parasitology , Volume 149 , Issue 8 , July 2022 , pp. 1019 - 1026
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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