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Modification of cellular immunity by Taenia multiceps (Cestoda): accessory macrophages and CD4+ lymphocytes are affected by two different coenurus factors

Published online by Cambridge University Press:  06 April 2009

N. K. Rakha ,
J. B. Dixon ,
P. Jenkins ,
S. D. Carter ,
G. C. Skerritt  and
S. Marshall-Clarke
N. K. Rakha
Affiliation:
Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX
P. Jenkins
Affiliation:
Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX
S. D. Carter
Affiliation:
Department of Veterinary Pathology, University of Liverpool, PO Box 147, Liverpool L69 3BX Department of Veterinary Clinical Science, University of Liverpool, PO Box 147, Liverpool L69 3BX
G. C. Skerritt
Affiliation:
Department of Veterinary Pre-clinical Science, University of Liverpool, PO Box 147, Liverpool L69 3BX
S. Marshall-Clarke
Affiliation:
Department of Human Anatomy and Cell Biology, University of Liverpool, PO Box 147, Liverpool L69 3BX
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Extract

Taenia multiceps coenurus fluid was analysed by fast protein liquid chromatography in order to separate the factors responsible for previously reported modification of immunological activity in macrophages and T-cells. One factor, F7, was found to be mitogenic for murine L3T4+ T-cells, to be macrophage dependent, to require macrophage compatibility at the I region of the H2 complex, to increase the sensitivity of T-cells to regulatory signals from macrophages and to increase the rate of generation of splenic rosette-forming cells (RFC) against sheep red cells. A second factor, F24, was found to alter macrophages so as to render them suppressive, rather than stimulatory, for parasite-activated and Con A-activated lymphocyte transformation, to depress the rate of generation of RFC and to antagonize the mitogenic effect of F7. The combined actions of these two factors are, therefore, sufficient to explain the known immunomodulatory effects of the metacestode.

Keywords

Taenia multicepscellular immunityaccessory cellmacrophageT-cell
Type
Research Article
Information
Parasitology , Volume 103 , Issue 1 , August 1991 , pp. 139 - 147
Copyright
Copyright © Cambridge University Press 1991

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