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Modelling inter-human transmission dynamics of Chagas disease: analysis and application

Published online by Cambridge University Press:  13 February 2014

M. C. FABRIZIO ,
N. J. SCHWEIGMANN  and
N. J. BARTOLONI
M. C. FABRIZIO*
Affiliation:
Departamento de Métodos Cuantitativos y Sistemas de Información, Facultad de Agronomía, Universidad de Buenos Aires, Av San Martín 4453, C1417DSE, Buenos Aires, Argentina
N. J. SCHWEIGMANN
Affiliation:
Departamento de Ecología, Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina
N. J. BARTOLONI
Affiliation:
Departamento de Métodos Cuantitativos y Sistemas de Información, Facultad de Agronomía, Universidad de Buenos Aires, Av San Martín 4453, C1417DSE, Buenos Aires, Argentina
*
* Corresponding author: Departamento de Métodos Cuantitativos y Sistemas de Información, Facultad de Agronomía, Universidad de Buenos Aires, Av San Martín 4453, C1417DSE, Buenos Aires, Argentina. E-mail: [email protected]
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Summary

Transmission of Trypanosoma cruzi, the causal agent of Chagas disease, has expanded from rural endemic to urban areas due to migration. This so-called urban Chagas is an emerging health problem in American, European, Australian and Japanese cities. We present a mathematical model to analyse the dynamics of urban Chagas to better understand its epidemiology. The model considers the three clinical stages of the disease and the main routes of inter-human transmission. To overcome the complexities of the infection dynamics, the next-generation matrix method was developed. We deduced expressions which allowed estimating the number of new infections generated by an infected individual through each transmission route at each disease stage, the basic reproduction number and the number of individuals at each disease stage at the outbreak of the infection. The analysis was applied to Buenos Aires city (Argentina). We estimated that 94% of the new infections are generated by individuals in the chronic indeterminate stage. When migration was not considered, the infection disappeared slowly and R 0 = 0·079, whereas when migration was considered, the number of individuals in each stage of the infection tended to stabilize. The expressions can be used to estimate different numbers of infected individuals in any place where only inter-human transmission is possible.

Keywords

Trypanosoma cruziurban Chagasmathematical modelnext-generation matrixbasic reproduction number
Type
Research Article
Information
Parasitology , Volume 141 , Issue 6 , May 2014 , pp. 837 - 848
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Copyright
Copyright © Cambridge University Press 2014 

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