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Low-dose oral administration of human interferon alpha can control the development of Theileria parva infection in cattle

Published online by Cambridge University Press:  06 April 2009

A. S. Young ,
A. C. Maritim ,
D. P. Kariuki ,
D. A. Stagg ,
J. M. Wafula ,
J. J. Mutugi ,
J. M. Cummins ,
A. B. Richards  and
C. Burns
A. S. Young
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
A. C. Maritim
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
D. P. Kariuki
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
D. A. Stagg
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
J. M. Wafula
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
J. J. Mutugi
Affiliation:
Protozoology Division, National Veterinary Research Centre, Muguga, Kenya Agricultural Research Institute, P.O. Box 32, Kikuyu, Kenya
J. M. Cummins
Affiliation:
Amarillo Cell Culture Company, Inc., Amarillo National's Plaza II, Amarillo, Texas 79105-0149, USA
A. B. Richards
Affiliation:
Campbell University, School of Pharmacy, Department of Pharmaceutical Sciences, Buies Creek, North Carolina 27506, USA
C. Burns
Affiliation:
Innovative Therapeutics (K) Ltd, P.O. Box 55844, Nairobi, Kenya
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Extract

Two natural human interferon alpha preparations, (nHuIFN-μ [Cantell]) and (Nhuifn-μ [ISI]), were used for the oral treatment of cattle experimentally infected with Theileria parva parva. In the first experiment, 8 Friesian bulls were inoculated with a 1 in 10 dilution of a sporozoite stabilate of T. p. parva (Marikebuni) stock. Four of the cattle were treated daily with 1 international unit/kg body weight (i.u./kg bwt) of nHuIFN-μ (Cantell) from day –2 to day 8 p.i. None of the 4 calves given IFN developed clinical theileriosis, but 3 of the 4 control calves died of theileriosis while the fourth had a mild infection. Three of 4 treated calves and the 1 surviving control calf developed a detectable antibody response to T. p. parva schizont antigen but, on challenged with a 10-fold higher dose of stabilate, the surviving control animal and only 1 of the 4 treated calves proved to be immune. In a second experiment, 4 groups of 4 calves were inoculated with the same stabilate dilution. Three treatment groups were given either 1 i.u. nHuIFN-μ (Cantell), 1 i.u. nHuIFN-μ (ISI), or 10 i.u. nHuIFN-μ (ISI)/kg bwt from day –2 to day 8 p.i. once daily and the fourth group were controls. Clinical theileriosis occurred in 2 controls, 2 calves given 10 i.u. nHuINF-μ (ISI), 1 calf given 1 i.u. nHuIFN-μ (ISI) and no calves given 1 i.u. nHuIFN-μ (Cantell)/kg bwt. Of these, 2, 1, 0 and 0 cattle died in the respective groups. All the surviving cattle proved to be immune on homologous challenge with 10-fold higher dose of stabilate except the 2 cattle which did not develop high antibody responses. A third experiment using an undiluted challenge of T. p. parva (Muguga) sporozoite stabilate (10α) on 8 steers. Four steers were treated with 1 i.u. nHuIFN-α (Cantell)/kg bwt and 4 were controls. All calves developed acute theileriosis and the experiment was terminated. Cells of the C2 lymphoblastoid cell line, infected with T. p. parva (Muguga) schizonts, were cultured in vitro with various concentrations (0-01-100 i.u./ml) of nHuIFN-a (Cantell). The IFN appeared to have no effect on host cell or parasite developmental variables when compared to untreated control cultures.

Keywords

Theileria parvatheileriosisE.st Coast fevertherapyinterferon μ
Type
Research Article
Information
Parasitology , Volume 101 , Issue 2 , October 1990 , pp. 201 - 209
Copyright
Copyright © Cambridge University Press 1990

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References

Balmer, C. M. (1985). The new alpha interferons. Drug Intelligence and Clinical and Pharmacy 19, 887–93.CrossRefGoogle ScholarPubMed
Billiau, A. (1984). The main concepts and achievements in interferon research: a historical account. In General and Applied Aspects, (ed. Billiau, A.), In Interferon, vol. 1 (ed. Finter, N. B.), pp. 23–60. Amsterdam: Elsevier.Google Scholar
Brocklesby, D. W., Barnett, S. F. & Scott, G. R. (1961). Morbidity and mortality rate in East Coast fever (Theileria parva infection) and their application to drug screening procedures. British Veterinary Journal 117, 529–31.CrossRefGoogle Scholar
Brown, C. G. D. (1979). Progation of Theileria. In Practical Tissue Culture Application, (ed. Moramorosch, K. & Hurumi, H.), pp. 223–54. New York: Academic Press.Google Scholar
Burridge, M. J. & Kimber, C. D. (1972). The indirect fluorescent antibody test for experimental East Coast fever (Theileria parva infection of cattle). Evaluation of a cell culture schizont antigen. Research in Veterinary Science 13, 451–5.CrossRefGoogle ScholarPubMed
Cantell, K. (1986). Clinical performance of natural human leukocyte interferon. Immunobiology 172, 231–42.CrossRefGoogle ScholarPubMed
Cantell, K. & Pyhala, L. (1973). Circulating interferon in rabbits after administration of human interferon by different routes. Journal of General Virology 20, 97–104.CrossRefGoogle ScholarPubMed
Cantell, K., Hirvonen, S., Kauppinen, H. L. & Myllyla, G. (1981 a). Production of interferon in human leukocytes from normal donors with the use of Sendai virus. Methods in Enzymology 78, 27–38.Google ScholarPubMed
Cantell, K., Hirvonen, S. & Koistinen, V. (1981 b). Partial purification of human leukocyte interferon on a large scale. Methods in Enzymology 78, 499–505.CrossRefGoogle ScholarPubMed
Castaigne, S., Sigaux, F., Cantell, K., Falcoff, E., Boiron, M., Flandrin, G. & Degos, L. (1986). Interferon alpha in the treatment of hairy cell leukemia. Cancer 57, 1681–4.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
Content, J. (1984). The antiviral effect of interferon on cells. In General and Applied Aspects, (ed. Billiau, A.), In Interferon, vol. 1 (ed. Finter, N. B.), pp. 125–38. Amsterdam: Elsevier.Google Scholar
Cummins, J. M. & Hutcheson, D. P. (1983). Effect of interferon on feedlot cattle. Proceedings of the American Association of Bovine Practitioners 15, 109–15.Google Scholar
Cummins, J. M. & Hutcheson, D. P. (1986). Low dosage of interferon to enhance vaccine efficiency in feedlot calves. Proceedings of the American Association of Bovine Practitioners 18, 135–8.Google Scholar
Cummins, J. M., Tompkins, M. B., Olsen, R. G., Tompkins, W. A. & Lewis, M. G. (1988). Oral use of human interferon in cats. Journal of Biological Response Modifiers 7, 513–23.Google ScholarPubMed
De Maeyer, E. (1984). Interferons and the immune system. In General and Applied Aspects, (ed. Billiau, A.), In Interferon, vol. 1 (ed. Finter, N. B.), pp. 167–88. Amsterdam: Elsevier.Google Scholar
Diez, R. A., Perdereau, B. & Falcoff, E. (1987). From old results to new perspectives: a look at interferon's fate in the body. Journal of Interferon Research 7, 553–7.CrossRefGoogle Scholar
Dolan, T. T., Young, A. S., Losos, G. J., McMillan, I., Minder, C. E. & Soulsby, K. (1984). Dose dependent responses of cattle to Theileria parva stabilate. International Journal for Parasitology 14, 89–95.CrossRefGoogle ScholarPubMed
Farrar, J. J., Benjamin, W. R. & Steeg, P. A. (1984). Regulatory interactions between the interferons and the interleukins. In Interferons and the Immune System, (ed. Vilcek, J. & De Maeyer, E.). In Interferon, vol. 2 (ed. Finter, N. B.), pp. 101–12. Amsterdam: Elsevier.Google Scholar
Fawcett, D. W., Doxsey, S., Stagg, D. A. & Young, A. S. (1982). The entry of sporozoites of Theileria parva in bovine lymphocytes in vitro. Electron microscopic observation. European Journal of Cell Biology 27, 10–21.Google Scholar
Goossens, A., Schwers, A., Vanden Broecke, C., Maenhoudt, M., Bugyaki, L., Pastoret, P. P. & Werenne, J. (1982). Antiviral efficiency of interferon in the bovine species: preliminary data on the activity in calves of bacterially produced human interferon (HuIFN-μ2). Archives Internationales de Physiologie et de Biochimie 90, B193.Google Scholar
Gresser, I. (1984). The effect of interferon on the expression of surface antigens. In Interferons and the Immune System, (ed. Vilcek, J. & De Maeyer, E.). In Interferon, vol. 2 (ed. Finter, N. B.), pp. 113–32. Amsterdam: Elsevier.Google Scholar
Herberman, R. B. (1984). Interferon and Cytotoxic effector cells. In Interferons and the Immune System, (ed. Vilcek, J. & De Maeyer, E.). In Interferon, vol. 2 (ed. Finter, N. B.), pp. 61–84. Amsterdam: Elsevier.Google Scholar
Irvin, A. D., Dobbelaere, D. A. E., Mwamachi, D. M., Minaml, T., Spooner, P. R. & Ocama, J. G. R. (1983). Immunization against East Coast fever: correlation between monoclonal antibody profiles of Theileria parva stocks and cross immunity in vivo. Research in Veterinary Science 35, 341–6.CrossRefGoogle ScholarPubMed
Isaacs, A. & Lindenmann, J. (1957). Virus interference. I. The Interferon. Proceedings of the Royal Society, B 147, 258–67.Google ScholarPubMed
Jameson, P. & Essex, M. (1983). Inhibition of feline leukemia virus replication by human leukocyte interferon. Antiviral Research 3, 115–20.CrossRefGoogle ScholarPubMed
Kelly, J. M. (1986). The role of interferons in parasitic protozoan infection. Parasitology Today, 2, 173–4.CrossRefGoogle ScholarPubMed
Kishida, T., Kita, M., Yamaji, M., Kaneto, E. & Teramatsu, T. (1987). Interferon producing capacity in patients with liver disease, diabetes mellitus, chronic diseases and malignant diseases. In Biology of the Interferon System, (ed. Cantell, K. & Schelleken, H.), pp. 435–41. Boston: Martinus Nijhoff Publishers.Google Scholar
Koech, D. K., Obel, A. O., Minowada, J., Hutchinson, W. A. & Cummins, J. M. (1990). Low dose oral alpha-interferon therapy for patents seropositive for the human immunodeficiency virus type-1 (HIV-1). Molecular Biotherapy, (in the Press).Google Scholar
Krakowka, S., Cummins, J. M. & Ringler, S. S. (1988). The effects of human interferon-alpha upon in vitro canine immune responses. Veterinary Immunology and Immunopathology 19, 185–96.CrossRefGoogle ScholarPubMed
Malmquist, W. A., Nyindo, M. B. A. & Brown, C. G. D. (1970). East Coast fever: cultivation in vitro of bovine spleen cell lines infected and transformed by Theileria parva. Tropical Animal Health and Production 2, 139–45.Google Scholar
Mutugi, J. J., Young, A. S., Linyonyi, A., Maritim, A. C., Mining, S. K., Ngumi, P. N., Morzaria, S. P. & Dolan, T. T. (1989). Immunization of cattle against theileriosis in Coast Province, Kenya. Laboratory evaluation of a large Theileria parva stabilate for use in the infection and treatment in the field. Research in Veterinary Science 47, 170–7.Google Scholar
Pestka, S., Langer, J. A., Zoon, K. C. & Samuel, C. E. (1987). Interferons and their actions. Annual Review of Biochemistry 56, 727–77.CrossRefGoogle ScholarPubMed
Quesada, J. R., Talpaz, M., Rios, A., Kurzrock, R. & Gutterman, J. U. (1986). Clinical toxicity of interferons in cancer patients: a review. Journal of Clinical Oncology 4, 234–43.CrossRefGoogle ScholarPubMed
Radley, D. E., Brown, C. G. D., Burridge, M. J., Cunningham, M. P., Peirce, M. A. & Purnell, R. E. (1974). East Coast fever: quantitative studies of Theileria parva in cattle. Experimental Parasitology 36, 278–87.Google Scholar
Roney, C. S., Rossi, C. R., Smith, P. C., Lauerman, L. C., Spano, J. S., Hanrahan, L. A. & William, J. C. (1985). Effect of human leukocyte interferon on prevention of infectious bovine rhinotracheitis virus infection of cattle. American Journal of Veterinary Research 46, 1251–5.Google ScholarPubMed
Rosenquist, B. N. & Loan, R. W. (1967). Interferon production with strain SF-4 of parainfluenza-3 virus. American Journal of Veterinary Research 28, 619–28.Google ScholarPubMed
Roth, M. A. & Zoon, K. A. (1986). Alpha interferon in the treatment of hematologic malignancies. American Journal of Medicine 81, 871–82.CrossRefGoogle ScholarPubMed
Schofield, L., Ferreira, A., Altszuler, R., Nussenzweig, V. & Nussenzweig, R. S. (1987). Interferon-λ inhibits the intrahepatocytic development of malaria parasites in vitro. Journal of Immunology 139, 2020–5.CrossRefGoogle Scholar
Schwers, A., Vanden Broecke, C., Goossens, A., Maenhoudt, M., Bugyaki, L., Pastoret, P. P. & Werenne, J. (1982). Administration of human interferon to young calves. Circulating antiviral activity and biologic response of the host. Archives Internationales de Physiologie et de Biochimie 90, B 214–5.Google Scholar
Sehgal, P. B. (1982). How many human interferons are there? Interferon 4, 1–22.Google Scholar
Sonnenfeld, G. (1984). Effects of interferon on antibody formation. In Interferons and the Immune System, (ed. Vilcek, J. & De Maeyer, E.). In Interferon, vol. 2 (ed. Finter, N. B.), pp. 85–100. Amsterdam: Elsevier.Google Scholar
Stagg, D. A., Young, A. S., Leitch, B. L. & Dolan, T. T. (1983). Infection of mammalian cells with theilerial species. Parasitology 86, 243–54.CrossRefGoogle Scholar
Stewart, W. E., II. (1981). The Interferon System, 2nd Edn. New York: Springer-Verlag.CrossRefGoogle Scholar
Taylor-Papadimitriou, J. (1984). Effects of interferons on cell growth and function. In General and Applied Aspects, (ed. Billiau, A.). In Interferon, vol. 1 (ed. Finter, N. B.), pp. 139–66. Amsterdam: Elsevier.Google Scholar
Vogel, S. N. & Friedman, R. M. (1984). Interferon and macrophages: activation and cell surface changes. In Interferons and the Immune System, (ed. Vilcek, J. & De Maeyer, E.). In Interferon, vol. 2 (ed. Finter, N. B.), pp. 35–60. Amsterdam: Elsevier.Google Scholar
Uilenberg, G. (1981). Theilerial species of domestic livestock. In Advances in the Control of Theileriosis, (ed. Irvin, A. D., Cunningham, M. P. & Young, A. S.), pp. 4–37. The Hague: Martinus Nijhoff Publishers.CrossRefGoogle Scholar
Young, A. S. (1981). The epidemiology of theileriosis in East Africa. In Advances in the Control of Theileriosis, (ed. Irvin, A. D., Cunningham, M. P. & Young, A. S.), pp. 38–55. The Hague: Martinus Nijhoff Publishers.CrossRefGoogle Scholar
Young, A. S. (1990). Theileriosis. In Encyclopedia of Immunology (ed. Roitt, I. & Delves, P.). London: Saunders Scientific Publications (in the Press).Google Scholar
Young, A. S., Groocock, C. M. & Kariuki, D. P. (1988). Integrated control of ticks and tick-borne diseases of cattle in Africa. Parasitology 96, 403–32.Google Scholar