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The larvicidal activity of cyclosporin A against Schistosoma mansoni in mice

Published online by Cambridge University Press:  06 April 2009

G. H. Munro ,
L. R. Brannan ,
L. H. Chappell ,
A. W. Thomson  and
D. J. McLaren
G. H. Munro
Affiliation:
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA
L. R. Brannan
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
L. H. Chappell
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
A. W. Thomson
Affiliation:
Department of Pathology, University Medical School, Forester Hill, Aberdeen AB9 2ZD
D. J. McLaren
Affiliation:
Division of Parasitology, National Institute for Medical Research, Mill Hill, London NW7 1AA
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Summary

Treatment of BALB/c or MF1 mice with cyclosporin A (CsA) around the time of infection with Schistosoma mansoni conferred almost complete protection. The migration kinetics of L-[75Se]selenomethionine-labelled infective cercariae were investigated by compressed tissue autoradiography. Similar levels of skin penetration were achieved by cercariae in control and drug-treated individuals. CsA arrested 87–94% of the worms in the skin and ultimately all of these died in this site. Few worms (7–14%) migrated from the skin to the lungs and none completed migration to the liver. Nevertheless, the autoradiograms revealed a limited degree of lateral cutaneous migration by the worms present in the skins of CsA-treated mice. Results of perfusion recovery experiments carried out during the course of infection reinforced the tracking data.

Keywords

Schistosoma mansonicyclosporin Aautoradiographic trackingchemotherapy
Type
Research Article
Information
Parasitology , Volume 102 , Issue 1 , February 1991 , pp. 57 - 63
Copyright
Copyright © Cambridge University Press 1991

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