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Kinetics of classes and sub-classes of total immunoglobulins and specific antibodies to Schistosoma mansoni during murine infection

Published online by Cambridge University Press:  06 April 2009

D. Bout ,
R. Rousseaux ,
Y. Carlier  and
A. Capron
D. Bout
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
R. Rousseaux
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
Y. Carlier
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
A. Capron
Affiliation:
Service d'Immunologie et de Biologie Parasitaire des U.E.R. de Médecine et de Pharmacie, et de l'Institut Pasteur de Lille
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Summary

During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specinc antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1; IgM and IgA. The maximum increase is respectively 26, 14 and 3-fold the basic immunoglobulin level in control mice. Some anti-S. mansoni classes and sub-classes were studied by an original radio-immunoadsorbent test. Anti-S. mansoni IgG1 and IgM antibodies appear and increase at the same time as that of total IgG1 and IgM. Anti-S. mansoni IgA antibodies appear later (80th day) and correspond to a second peak of total IgA.

Type
Research Article
Information
Parasitology , Volume 80 , Issue 2 , April 1980 , pp. 247 - 256
Copyright
Copyright © Cambridge University Press 1980

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