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Interactive effects of protein nutrition, genetic growth potential and Heligmosomoides bakeri infection pressure on resilience and resistance in mice

Published online by Cambridge University Press:  18 July 2011

JENNIFER C. COLTHERD ,
SIMON A. BABAYAN ,
LUTZ BÜNGER ,
ILIAS KYRIAZAKIS ,
JUDITH E. ALLEN  and
JOS G. M. HOUDIJK
JENNIFER C. COLTHERD*
Affiliation:
Animal Health, SAC, West Mains Road, Edinburgh EH9 3JG, UK
SIMON A. BABAYAN
Affiliation:
Centre for Immunity, Infection & Evolution and Institute of Immunology and Infection Research, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK
LUTZ BÜNGER
Affiliation:
Sustainable Livestock Systems, SAC, West Mains Road, Edinburgh EH9 3JG, UK
ILIAS KYRIAZAKIS
Affiliation:
Animal Health, SAC, West Mains Road, Edinburgh EH9 3JG, UK
JUDITH E. ALLEN
Affiliation:
Centre for Immunity, Infection & Evolution and Institute of Immunology and Infection Research, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK
JOS G. M. HOUDIJK
Affiliation:
Animal Health, SAC, West Mains Road, Edinburgh EH9 3JG, UK
*
*Corresponding author: Disease Systems Team, SAC, West Mains Road, Edinburgh EH9 3JG, UK. Tel: +44 (0) 131 5353058. Fax: +44 0 131 5353121. E-mail: [email protected]
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Summary

The ability of animals to cope with an increasing parasite load, in terms of resilience and resistance, may be affected by both nutrient supply and demand. Here, we hypothesized that host nutrition and growth potential interact and influence the ability of mice to cope with different parasite doses. Mice selected for high (ROH) or low (ROL) body weight were fed a low (40 g/kg; LP) or high (230 g/kg; HP) protein diet and infected with 0, 50, 100, 150, 200 or 250 L3 infective Heligmosomoides bakeri larvae. ROH-LP mice grew less at doses of 150 L3 and above, whilst growth of ROH-HP and of ROL mice was not affected by infection pressure. Total worm burdens reached a plateau at doses of 150L3, whilst ROH mice excreted fewer worm eggs than ROL mice. Serum antibodies increased with infection dose and ROH mice were found to have higher parasite-specific IgG1 titres than ROL mice. In contrast, ROL had higher total IgE titres than ROH mice, only on HP diets. The interaction between host nutrition and growth potential appears to differentially affect resilience and resistance in mice. However, the results support the view that parasitism penalises performance in animals selected for higher growth.

Keywords

minimum level of parasitismHeligmosomoides bakeriprotein nutritiongrowth potentialresilienceresistanceserum antibodymice
Type
Research Article
Information
Parasitology , Volume 138 , Issue 10 , September 2011 , pp. 1305 - 1315
Copyright
Copyright © Cambridge University Press 2011

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