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Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis

Published online by Cambridge University Press:  16 April 2008

P. A. KNIGHT ,
J. K. BROWN  and
A. D. PEMBERTON
P. A. KNIGHT*
Affiliation:
Department of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
J. K. BROWN
Affiliation:
Department of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
A. D. PEMBERTON
Affiliation:
Department of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK
*
*Corresponding author: Department of Veterinary Clinical Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK. Tel: +0131 650 7348. Fax: +0131 651 3903. E-mail: [email protected]
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Summary

Gastrointestinal infection with the nematode Trichinella spiralis is accompanied by a rapid and reversible expansion of the mucosal mast cell and goblet cell populations in the intestinal epithelium, which is associated with the release of their mediators into the gut lumen. Both goblet cell and mast cell hyperplasia are highly dependent on mucosal T-cells and augmented by the cytokines IL-4 and IL-13. However, the contribution of both mast and goblet cells, and the mediators they produce, to the expulsion of the adults of T. spiralis is only beginning to be elucidated through studies predominantly employing T. spiralis-mouse models. In the present article, we review the factors proposed to control T. spiralis-induced mucosal mast cell (MMC) and goblet cell differentiation in the small intestine, and focus on some key MMC and goblet cell effector molecules which may contribute to the expulsion of adult worms and/or inhibition of larval development.

Keywords

Trichinella spiralisgastrointestinal nematodesmast cellsgoblet cellscytokinesmucusMcpt-1Mcpt-2intelectinRELMβ
Type
Review Article
Information
Parasitology , Volume 135 , Issue 6 , May 2008 , pp. 655 - 670
Copyright
Copyright © 2008 Cambridge University Press

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