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The influence of Nematospiroides dubius on subsequent Nippostrongylus brasiliensis infections in mice

Published online by Cambridge University Press:  06 April 2009

D. Conwil Jenkins
D. Conwil Jenkins
Affiliation:
Pharmaceutical Research Laboratories, May & Baker Ltd, Dagenham, Essex
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Extract

The fecundity and longevity of Nippostrongylus brasiliensis was prolonged in mice previously infected with Nematospiroides dubius only when the former developed from the larval stage in those mice. Such worms appeared to be less immunogenic than worms which developed in mice never exposed to N. dubius.

It is proposed that prolonged fecundity and longevity resulted from an adaptation undertaken by the worms in the face of host antibodies which had been developed against the pre-existing N. dubius infection.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 2 , October 1975 , pp. 349 - 355
Copyright
Copyright © Cambridge University Press 1975

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References

Bartlett, A. & Ball, P. A. J. (1974). The immune response of the mouse to larvae and adults of Nematospiroides dubius. International Journal for Parasitology 4, 463–70.Google Scholar
Colwell, D. A. & Wescott, R. B. (1973). Prolongation of egg production of Nippostrongylus brasiliensis in mice concurrently infected with Nematospiroides dubius. Journal of Parasitology 59, 216.Google Scholar
Jenkins, D. C. (1972). Nippostrongylus brasiliensis: observations on the comparative immunogenicity of adult worms from primary and immune-adapted infections. Parasitology 65, 547–50.CrossRefGoogle ScholarPubMed
Jenkins, D. C. & Phillipson, R. F. (1971). The kinetics of repeated low-level infections of Nippostrongylus brasiliensis in the laboratory rat. Parasitology 62, 457–65.Google Scholar
Jenkins, D. C. & Phillipson, R. F. (1972 a). Increased establishment and longevity of Nippostrongylus brasiliensis in immune rats given repeated small challenge infections. International Journal for Parasitology 2, 105–11.Google Scholar
Jenkins, D. C. & Phillipson, R. F. (1972 b). Evidence that the nematode Nippostrongylus brasiliensis can adapt to and overcome the effects of host immunity. International Journal for Parasitology 2, 353–9.Google Scholar
Ogilvie, B. M. (1969). Immunity to Nippostrongylus brasiliensis. Symposia of the British Society for Parasitology 7, 31–40.Google Scholar
Ogilvie, B. M. & Hockley, D. J. (1968). Effects of immunity on Nippostrongylus brasiliensis adult worms: reversible and irreversible changes in infectivity, reproduction and morphology. Journal of Parasitology 54, 1073–84.Google Scholar