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Impact of community-directed treatment on soil transmitted helminth infections in children aged 12 to 59 months in Mazabuka District, Zambia

Published online by Cambridge University Press:  15 February 2011

HIKABASA HALWINDI ,
PASCAL MAGNUSSEN ,
SETER SIZIYA ,
RAY HANDEMA ,
DAN W. MEYROWITSCH  and
ANNETTE OLSEN
HIKABASA HALWINDI*
Affiliation:
Department of Biological Sciences, School of Natural Sciences, University of Zambia, Box 32379 Lusaka, Zambia
PASCAL MAGNUSSEN
Affiliation:
DBL-Centre for Health Research and Development, Department of Veterinary Disease Biology, Faculty of Life Sciences, Thorvaldsensvej 57, DK-1871 Frederiksberg C
SETER SIZIYA
Affiliation:
Department of Community Medicine, School of Medicine, University of Zambia, Box 50110 Lusaka, Zambia
RAY HANDEMA
Affiliation:
Department of Biological Sciences, School of Natural Sciences, University of Zambia, Box 32379 Lusaka, Zambia
DAN W. MEYROWITSCH
Affiliation:
Section of Health Services Research, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1353 Copenhagen K, Denmark
ANNETTE OLSEN
Affiliation:
DBL-Centre for Health Research and Development, Department of Veterinary Disease Biology, Faculty of Life Sciences, Thorvaldsensvej 57, DK-1871 Frederiksberg C
*
*Corresponding author: Hikabasa Halwindi, Department of Biological Sciences, University of Zambia, Box 32379 Lusaka, Zambia. Tel.: +260 955 754 563. E-mail: [email protected]
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Summary

This study assessed the impact of adding community-directed treatment (ComDT) to the routine health facility (HF)-based treatment on prevalence and intensity of soil transmitted helminth (STH) infections among children aged 12 to 59 months. Repeated cross-sectional surveys were conducted among randomly selected children of this age group from the intervention area (HF+ComDT area) and the comparison area (HF area) at baseline (n=986), 12 months (n=796) and 18 months (n=788) follow-up. The prevalence of Ascaris lumbricoides was significantly higher in the HF+ComDT as compared to the HF area at baseline (P=0·048), but not at 12 and 18 months follow-up. At baseline the HF+ComDT area had significantly higher intensities of A. lumbricoides compared to the HF area (P<0·001), but not at 12 and 18 months follow-ups. Prevalence and intensity of hookworm did not differ significantly between treatment arms at any time. Analysis of trends showed a significant decrease in prevalence of A. lumbricoides and hookworm in the HF+ComDT area (P<0·001), of hookworm in the HF area (P<0·05), but not of A. lumbricoides in the HF area. It is concluded that the ComDT approach generally enhanced the treatment effect among under-five year children and that this alternative approach may also have advantages in other geographical settings.

Keywords

Soil transmitted helminthiasiscommunity-directed treatmenthealth facilitychild health weekunder-five childrenZambia
Type
Research Article
Information
Parasitology , Volume 138 , Special Issue 12: Symposia of the British Society for Parasitology Volume 47 , October 2011 , pp. 1578 - 1585
Copyright
Copyright © Cambridge University Press 2011

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References

REFERENCES

Albonico, M., Allen, H., Chitsulo, L., Engels, D., Gabrielli, A. F. and Savioli, L. (2008). Controlling soil-transmitted helminthiasis in pre-school-age children through preventive chemotherapy. PLoS Neglected Tropical Diseases 2, e126. doi:10.1371/journal.pntd.0000126CrossRefGoogle ScholarPubMed
Albonico, M., Bickle, Q., Ramsan, M., Montresor, A., Salvioli, L. and Taylor, M. (2003). Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bulletin of the World Health Organization 81, 343–352.Google ScholarPubMed
APOC (1998). Community-directed treatment with ivermectin: A practical guide for trainers of community-directed distributors. APOC, OuagadougouGoogle Scholar
Bain, G. A. and Flower, C. D. (1996). Pulmonary eosinophilia. European Journal of Radiolology 23, 3–8. doi:10.1016/0720-048X(96)01029-7CrossRefGoogle ScholarPubMed
Bennett, S., Woods, T., Liyanage, W. M. and Smith, D. L. (1991). A simplified general method for cluster-sample surveys of health in developing countries. World Health Statistics Quarterly 44, 98–106.Google ScholarPubMed
Conteh, L., Engels, T. and Molyneux, D. H. (2010). Socioeconomic aspects of neglected tropical diseases. Neglected Tropical Diseases 4. The Lancet 375, 239–47.CrossRefGoogle Scholar
Crompton, D. W. T. and Savioli, L. (2007). Handbook of Helminthiasis for Public Health. CRC Press, Taylor and Francis Group, USA.Google Scholar
Curtis, V., Kanki, B., Mertens, T., Traoré, E., Diallo, I., Tall, F. and Cousens, S. (1995). Potties, pits and pipes: explaining hygienic behaviour in Burkina Faso. Social Science and Medicine 41, 383–393.CrossRefGoogle ScholarPubMed
Hall, A. and Holland, C. (2000). Geographical variation in Ascaris lumbricoides fecundity and its implications for helminth control. Parasitology Today 16, 540–544.CrossRefGoogle ScholarPubMed
Halwindi, H. (2010). Community-directed treatment of soil transmitted helminths in children aged 12 to 59 months of Mazabuka district in Zambia. PhD thesis, University of Copenhagen.Google Scholar
Halwindi, H., Magnussen, P., Meyrowitsch, D., Handema, R., Siziya, S. and Olsen, A. (2010). Impact of adding community-directed treatment to the health facility approach on treatment coverage against soil transmitted helminths in under-five children of Mazabuka District, Zambia. International Health 2, 253–261. doi:10.1016/j.inhe.2010.09·003CrossRefGoogle Scholar
Keiser, J. and Utzinger, J. (2008). Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. Journal of the American Medical Association 299, 1937–1948. doi:10.1001/jama.299.16.1937Google ScholarPubMed
Ministry of Health/Central Board of Health. (2003). National plan of action for control of schistosomiasis in Zambia. MoH/CBoH, Zambia.Google Scholar
Montresor, A., Awasthi, S. and Cromptom, D. W. T. (2003). Use of benzimidazoles in children younger than 24 months for the treatment of soil-transmitted helminthiasis. Acta Tropica 86, 223–232.CrossRefGoogle ScholarPubMed
Shapiro, A. E., Tukahebwa, E. M., Kasten, J., Clarke, S. E., Magnussen, P., Olsen, A., Kabatereine, N. B., Ndyomugyenyi, R. and Brooker, S. (2005). Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene 99, 18–24.CrossRefGoogle ScholarPubMed
Stoltzfus, R. J., Chway, H. M., Montresor, A., Tielsch, J. M., Jape, K. J., Albonico, M. and Savioli, L. (2004). Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children. Journal of Nutrition 134, 348–356.Google Scholar
Stothard, J. R., Imison, E., French, M. D., Sousa-Figueiredo, J. C., Khamis, I. S. and Rollinson, D. (2008). Soil-transmitted helminthiasis among mothers and their pre-school children on Unguja Island, Zanzibar with emphasis upon ascariasis. Parasitology 135, 1447–1455. doi:10.1017/S0031182008004836CrossRefGoogle ScholarPubMed
TDR (2008). Community-directed interventions for major health problems in Africa. A multi-country study final report. UNICEF/UNDP/World Bank/WHO.Google Scholar
The Partnership for Child Development. (1997). Better health, nutrition and education for the school-aged child. Transactions of the Royal Society of Tropical Medicine and Hygiene 91, 1–2.CrossRefGoogle Scholar
WHO (1999). Monitoring Helminth Control Programs, WHO/CDS/CPC/SIP/99.3.Google Scholar
WHO (2002). Helminth control in school-age children. A guide to managers of control programmes. World Health Organization, Geneva.Google Scholar
WHO (2004). Bench aids for diagnosis of intestinal helminths. World Health Organization, Geneva.Google Scholar
WHO (2005). Report of the third global meeting of the partners for parasite control: Deworming for health and development. Geneva 29–30 November 2004.Google Scholar
WHO (2006 a). Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions. A manual for health professionals and programme managers.Google Scholar
WHO (2006 b). Schistosomiasis and soil-transmitted helminth infections – preliminary estimates of the number of children treated with albendazole or mebendazole. Weekly epidemiological record 16: 81, 145–164. Geneva.Google Scholar
WHO & UNICEF (2004). How to add deworming to vitamin A distribution. Geneva: World Health Organization.Google Scholar