Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-06T05:14:31.024Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunity to Trichinella spiralis

I. The immunity produced by mice to the first four days of the intestinal phase of the infection

Published online by Cambridge University Press:  06 April 2009

D. A. Denham
D. A. Denham
Affiliation:
Department of Animal Pathology, Madingley Road, Cambridge*
Get access Rights & Permissions [Opens in a new window]

Extract

Single infections of Trichinella spiralis of 48 h duration did not produce a significant degree of immunity in mice.

Single or triple light infections of 7 h duration which, it is suggested, were composed entirely of fourth-stage larvae, did not produce significant immunity.

Single infections of 3 or 4 days duration did produce immunity. It is suggested that the fourth-stage intestinal larvae and the fourth moult are not the most important sources of immunizing antigen in a T. spiralis infection.

I would like to express my gratitude to H.M. Treasury and to the Agricultural Research Council for financial support during the time that this work was being conducted. I would also like to thank Professor W. I. B. Beveridge, within whose department this work was conducted, for the facilities provided. The helpful advice of my colleagues R. M. Connan and R. S. Phillips was of great value during the time that this manuscript was being prepared for publication.

Type
Research Article
Information
Parasitology , Volume 56 , Issue 2 , May 1966 , pp. 323 - 327
Copyright
Copyright © Cambridge University Press 1966

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Berntzen, A. K. (1965). Comparative growth and development of Trichinella spiralis in vitro and in vivo, with a redescription of the life-cycle. Expl Parasit. 16, 74–106.Google Scholar
Campbell, W. C. (1965). Immunizing effect of enteral and enteral–parenteral infections of Trichinella spiralis in mice. J. Parasit. 51, 185–94.Google Scholar
Campbell, W. C. & Cuckler, A. C. (1964). Effect of thiabendazole upon the enteral and parenteral phases of trichinosis in mice. J. Parasit. 50, 481–8.Google Scholar
Campbell, W. C., Hartman, R. K. & Cuckler, A. C. (1963). Induction of immunity to trichinosis in mice by means of chemically abbreviated infections. Expl Parasit. 14, 19–36.Google Scholar
Chandler, A. C. (1936). Studies on the nature of immunity to intestinal helminths. IV. The interrelationships between parenteral and intestinal immunity in rats infected with Nippostrongylus. Am. J. Hyg. 24, 129–44.Google Scholar
Denham, D. A. (1965). Studies with methyridine and Trichinella spiralis. 1. Effect upon the intestinal phase in mice. Expl Parasit. 17, 10–14.Google Scholar
Gould, S. E., Gomberg, H. J., Bethell, F. H., Villella, J. B. & Hertz, C. S. (1955). Studies on Trichinella spiralis. II. Time of initial recovery of Trichinella spiralis larvae from blood of experimental animals. Am. J. Path. 31, 936–42.Google Scholar
Kim, C. W. (1957). Immunity to Trichinella spiralis in mice infected with irradiated larvae. J. Elisha Mitchell scient. Soc. 73, 308–17.Google Scholar
Larsh, J. E. (1963). Experimental trichiniasis. Adv. Parasit. 1, 213–86.Google Scholar
Ogilvie, B. M. (1965). Role of adult worms in immunity of rats to Nippostrongylus brasiliensis. Parasitology, 55, 325–35.Google Scholar