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Immune-dependent chemotherapy of schistosomiasis

Published online by Cambridge University Press:  06 April 2009

P. G. Fallon ,
R. O. Cooper ,
A. J. Probert  and
M. J. Doenhoff
P. G. Fallon
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
R. O. Cooper
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
A. J. Probert
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
M. J. Doenhoff
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
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Summary

Host immune responses have been shown to enhance the efficacy of several schistosomicidal drugs. The evidence derives mainly from experiments on Schistosoma mansoni infections in the mouse with their immune status variously modulated; this review emphasises praziquantel (PZQ), which is now the main drug used for treatment of human schistosomiasis. Electron microscopy and indirect immunofluorescence indicate that PZQ disrupts the integrity of the surface membranes of S. mansoni, particularly those covering the dorsal tubercles of adult male worms, and this causes antigens which are the targets of antibody attack to be revealed. We review the evidence that two S. mansoni antigens in particular are implicated in the immune-dependent action of PZQ: a 200 kDa glycoprotein and a 27 kDa antigen with non-specific esterase activity.

Keywords

ChemotherapyschistosomiasisSchistosoma mansonipraziquantelimmune-dependence
Type
Research Article
Information
Parasitology , Volume 105 , Issue S1: Chemotherapy and the immune system , January 1992 , pp. S41 - S48
Copyright
Copyright © Cambridge University Press 1992

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