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Host protective humoral immune responses to Schistosoma mansoni infections in the rat. Kinetics of hyperimmune serum-dependent sensitivity and elimination of schistosomes in a passive transfer system

Published online by Cambridge University Press:  06 April 2009

Beverley L. Mangold  and
P. M. Knopf
Beverley L. Mangold
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
P. M. Knopf
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
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Summary

A passive transfer system, dependent upon hyperimmune rat serum, was used to study in vivo protective humoral immunity to Schistosoma mansoni infection in Fischer rats. Infected recipients of hyperimmune serum exhibited a significant reduction (51%) in the number of recovered adult schistosomes relative to infected recipients of normal rat serum. Furthermore, schistosomula were equally sensitive to the effects of hyperimmune serum injected up to and including 7 days post-infection, a phenomenon which was termed ‘extended sensitivity’. Schistosomula were beginning to lose sensitivity to the effects of hyperimmune serum by the 8th day post-infection and were completely refractile by the 9th day. In addition, it was demonstrated that parasite elimination occurred after the lung stage. Some protection was also observed when hyperimmune rat serum was transferred to mice as late as 5 days post-infection.

Type
Research Article
Information
Parasitology , Volume 83 , Issue 3 , December 1981 , pp. 559 - 574
Copyright
Copyright © Cambridge University Press 1981

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