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Host immune response and pathological expression in malaria: possible implications for malaria vaccines

Published online by Cambridge University Press:  23 August 2011

G. E. Grau ,
G. Del Giudice  and
P.-H. Lambert
G. E. Grau
Affiliation:
World Health Organization Immunology Research and Training Centre, Department of Pathology, University of Geneva, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
G. Del Giudice
Affiliation:
World Health Organization Immunology Research and Training Centre, Department of Pathology, University of Geneva, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
P.-H. Lambert
Affiliation:
World Health Organization Immunology Research and Training Centre, Department of Pathology, University of Geneva, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland
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Extract

Recent progress in parasite immunobiology has led to the identification of several plasmodial antigens representing the target of the protective antibody response of the infected host. As a consequence, some of these antigens have been envisaged as potential malaria vaccines in man. However, in spite of these achievements, the fine mechanisms which lead to the development of a state of partial protective immunity or to the triggering of immunopathology during malaria infection are not yet fully understood. Thus, it may be appropriate to evaluate the relative importance of individual host immune responsiveness to parasite epitopes involved in the induction of immunity, or of some immunologically mediated adverse reactions such as glomerulonephritis, anaemia, thrombocytopenia, and cerebral syndrome.

Type
Research Article
Information
Parasitology , Volume 94 , supplement S1: Symposia of the British Society for Parasitology Volume 24 Pathophysiological responses to parasites , January 1987 , pp. S123 - S137
Copyright
Copyright © Cambridge University Press 1987

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