Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-28T05:53:10.239Z Has data issue: false hasContentIssue false
  • English
  • Français

Further studies on the use of chicken embryo infections for the study of drug resistance in Eimeria tenella

Published online by Cambridge University Press:  06 April 2009

H. D. Chapman
H. D. Chapman
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
Get access Rights & Permissions [Opens in a new window]

Extract

Infections in the chicken embryo have been used to study the development of drug resistance in an embryo adapted strain of E. tenella. Resistance was developed to decoquinate, clopidol and robenidine by serially passaging this strain, but evidence for the development of resistance to amprolium was inconclusive. Resistance to decoquinate developed more readily than to the other drugs. Attempts to increase resistance to clopidol, robenidine and amprolium by increasing the sporozoite inoculum and by the use of a mutagenic agent were unsuccesful. No cross-resistance was found between the 4 drugs.

Drug resistant lines of the Houghton strain (H) of E. tenella, made resistant to the 4 anticoccidial drugs by passage in chickens, were found to be resistant when evaluated using chicken embryo infections. Lines made resistant to decoquinate were not controlled by any concentration of this drug, suggesting that resistance, once developed, was absolute and not dependent on drug concentration. Lines made resistant to robenidine, clopidol and amprolium, however, were controlled by higher drug concentrations suggesting that in this case resistance was dependent on drug concentration.

Type
Research Article
Information
Parasitology , Volume 73 , Issue 3 , December 1976 , pp. 275 - 282
Copyright
Copyright © Cambridge University Press 1976

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chapman, H. D. (1974). Use of chick embryo infections for the study of drug resistance in Eimeria tenella. Parasitology 69, 283–90.CrossRefGoogle Scholar
Chapman, H. D. (1975). Eimeria tenella in chickens: development of resistance to quinolone anticoccidial drugs. Parasitology 71, 41–9.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. (1970). Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain. Avian Diseases 14, 126–30.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Chute, M. B. (1971). Efficacy of decoquinate against eleven strains of Eimeria tenella and development of a decoquinate resistant strain. Avian Diseases 15, 342–5.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Chute, M. B. (1973). Efficacy of nequinate against thirteen strains of Eimeria tenella and the development of a nequinate resistant strain. Avian Diseases 17, 717–21.CrossRefGoogle ScholarPubMed
McLoughlin, D. K. & Gardiner, J. L. (1968). Drug resistance in Eimeria tenella. VI. The experimental development of an amprolium resistant strain. Journal of Parasitology 54, 582–4.CrossRefGoogle ScholarPubMed
Norton, C. C. & Joyner, L. P. (1975). The development of drug-resistant strains of Eimeria maxima in the laboratory. Parasitology 71, 153–65.CrossRefGoogle ScholarPubMed
Peters, W. (1970). Chemotherapy and Drug Resistance in Malaria. New York and London: Academic Press.Google Scholar
Ryley, J. F. & Betts, M. J. (1973). Chemotherapy of chicken coccidiosis. Advances in Pharmacology and Chemotherapy 11, 221–93.CrossRefGoogle ScholarPubMed
Schnitzer, R. J. (1963). Experimental chemotherapy. In Drug Resistance in Chemotherapy. A general outline, vol. 1 (ed. R. J., Schnitzer and F., Hawking), pp. 81–128. New York: Academic Press.Google Scholar