Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T01:03:51.285Z Has data issue: false hasContentIssue false
  • English
  • Français

Further observations on immunization of sheep against Schistosoma mansoni and S. bovis using irradiation -attenuated schistosomula of homologous and heterologous species

Published online by Cambridge University Press:  06 April 2009

Q. D. Bickle ,
M. G. Taylor ,
E. R. James ,
G. S. Nelson ,
M. F. Hussein ,
B. J. Andrews ,
A. R. Dobinson  and
T. F. de C. Marshall
Q. D. Bickle
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
M. G. Taylor
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
E. R. James
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
G. S. Nelson
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
M. F. Hussein
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
B. J. Andrews
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
A. R. Dobinson
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
T. F. de C. Marshall
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
Get access Rights & Permissions [Opens in a new window]

Summary

This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiated schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated S. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection.

Type
Research Article
Information
Parasitology , Volume 78 , Issue 2 , April 1979 , pp. 185 - 193
Copyright
Copyright © Cambridge University Press 1979

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Dargie, J. D., Berry, C. I., Holmes, P. H., Taylor, M. G., James, E. R. & Nelson, G. S. (1977). Studies on the pathogenesis of a strain of Schistosoma mattheei maintained in hamsters. Journal of Helminthology 51, 177–8.CrossRefGoogle ScholarPubMed
Dargie, J. D., Berry, C. I., Holmes, P. H., Reid, J. F. S., Breeze, R., Taylor, M. G., James, E. R. & Nelson, G. S. (1977). Immunisation of sheep against a virulent strain of Schistosoma mattheei using a strain of S. mattheei attenuated by hamster passage. Journal of Helminthology 51, 347–57.CrossRefGoogle ScholarPubMed
Hussein, M. F. & Bushara, H. O. (1976). Investigations on the development of an irradiated vaccine for animal schistosomiasis. In Nuclear Techniques in Animal Production and Health, pp. 421–31. Vienna: International Atomic Energy Agency.Google Scholar
Hussein, M. F., Saeed, A. A. & Nelson, G. S. (1970). Studies on heterologous immunity in schistosomiasis. 4. Heterologous schistosome immunity in cattle. Bulletin of the World Health Organization 42, 745–9.Google ScholarPubMed
James, E. R. & Taylor, M. G. (1976). Transformation of cercariae to schistosomula: a quantitative comparison of transformation techniques and of infectivity by different injection routes of the organisms produced. Journal of Helminthology 50, 223–33.CrossRefGoogle ScholarPubMed
Massoud, J. & Nelson, G. S. (1972). Studies on heterologous immunity in schistosomiasis. 6. Observations on cross-immunity to Ornithobilharzia turkestanicum, Schistosoma bovis, S. mansoni and S. haematobium in mice, sheep and cattle in Iran. Bulletin of the World Health Organization 47, 591–600.Google Scholar
Minard, P., Dean, D. A., Jacobson, R. H., Vannier, W. E. & Murrell, K. D. (1978). Immunization of mice with cobalt-60 irradiated Schistosoma mansoni cercariae. American Journal of Tropical Medicine and Hygiene 27, 76–86.CrossRefGoogle ScholarPubMed
Preston, J. M., Nelson, G. S. & Saeed, A. A. (1972). Studies on heterologous immunity in schistosomiasis. 5. Heterologous schistosome immunity in sheep. Bulletin of the World Health Organization 47, 587–90.Google ScholarPubMed
Taylor, M. G. (1975). Towards the development of a live vaccine for schistosomiasis. In Nuclear Techniques in Helminthology Research, pp. 165–73. Vienna: International Atomic Energy Agency.Google Scholar
Taylor, M. G., James, E. R., Nelson, G. S., Bickle, Q. D., Dunne, D. W. & Webbe, G. (1976). Immunisation of sheep against Schistosoma mansoni using either irradiated cercariae or irradiated schistosomula. Journal of Helminthology 50, 1–9.CrossRefGoogle ScholarPubMed
Taylor, M. G., James, E. R., Nelson, G. S., Bickle, Q., Dunne, D. W., Dobinson, A. R., Dargie, J. D., Berry, C. I. & Hussein, M. F. (1977). Modification of the pathogenicity of Schistosoma mattheei for sheep by passage of the parasite in hamsters. Journal of Helminthology 51, 337–45.CrossRefGoogle ScholarPubMed
Taylor, M. G., James, E. R., Bickle, Q. D., Hussein, M. F., Andrews, B. J., Dobinson, A. R. & Nelson, G. S. (1978). Immunisation of sheep against Schistosoma bovis using an irradiated schistosomular vaccine. Journal of Helminthology 52 (in the Press).Google Scholar