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Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico

Published online by Cambridge University Press:  04 September 2006

E. SCIUTTO ,
J. MORALES ,
J. J. MARTÍNEZ ,
A. TOLEDO ,
M. N. VILLALOBOS ,
C. CRUZ-REVILLA ,
G. MENESES ,
M. HERNÁNDEZ ,
A. DÍAZ  and
L. F. RODARTE
...Show all authors
E. SCIUTTO
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
J. MORALES
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
J. J. MARTÍNEZ
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
A. TOLEDO
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
M. N. VILLALOBOS
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
C. CRUZ-REVILLA
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
G. MENESES
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
M. HERNÁNDEZ
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
A. DÍAZ
Affiliation:
Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, México
L. F. RODARTE
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
G. ACERO
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
G. GEVORKIAN
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
K. MANOUTCHARIAN
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
J. PANIAGUA
Affiliation:
Laboratorios Silanes, Amores # 1304, Col. Del Valle, México, D.F. México
G. FRAGOSO
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
A. FLEURY
Affiliation:
Instituto Nacional de Neurología y Neurocirugía, Insurgentes Sur 3877, Col. Las Famas, 14269 México, D.F. México
R. LARRALDE
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
A. S. DE ALUJA
Affiliation:
Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Circuito de la Investigación Científica, Ciudad Universitaria, 04510 México, D.F. México
C. LARRALDE
Affiliation:
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, Ciudad Universitaria, 04510 México, D.F. México
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Abstract

Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine cysticercosis has been developed previously as an aid to interrupt transmission and has been shown to be effective. The results of the present study support the effectiveness of the vaccine under endemic field conditions. However, given the time-frame of the vaccination trial, no changes in the local levels of transmission were detectable before and after vaccination using sentinel pigs. Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region.

Keywords

Taenia soliumcysticercosiscontrolvaccinationfield evaluation
Type
Research Article
Information
Parasitology , Volume 134 , Issue 1 , January 2007 , pp. 129 - 133
Copyright
© 2006 Cambridge University Press

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