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Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. The effect of varying the route and the number of primary infections, and the correlation between the size of the primary infection and the degree of resistance that is acquired

Published online by Cambridge University Press:  06 April 2009

E. Long ,
R. Harrison ,
Q. Bickle ,
J. Bain ,
G. Nelson  and
M. Doenhoff
E. Long
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
R. Harrison
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
Q. Bickle
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
J. Bain
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
G. Nelson
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
M. Doenhoff*
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ
*
2M. Doenhoff, Winches Farm Field Station, 395 Hatfield Road, St Albans AL4 OXQ.
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Summary

Mice given primary infections of Schistosoma mansoni by percutaneous or subcutaneous routes were found to acquire a higher degree of resistance against homologous challenge after 7–8 weeks than mice infected intraperitoneally. Mice infected by the intraperitoneal route tended to have smaller worm burdens than those infected with the same number of cercariae by the other two routes and this may, in part, have contributed to the relative lack of efficacy of intraperitoneal infections in inducing resistance to re-infection. The same degree of resistance was acquired after primary percutaneous infection irrespective of whether it was administered in 3 equivalent weekly doses, or the same total number of cercariae was administered as a single infection. The same degree of resistance was also observed when a percutaneous challenge was administered on the same or a different skin site to that which received the percutaneous primary infection. The degree of resistance to re-infection acquired after a percutaneous primary infection correlated well with the size of the primary worm burden and the number of eggs in the intestine and liver, but did not correlate with the number of eggs in the lungs.

Type
Research Article
Information
Parasitology , Volume 81 , Issue 2 , October 1980 , pp. 355 - 371
Copyright
Copyright © Cambridge University Press 1980

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References

REFERENCES

Bickle, Q., Bain, J., McGregor, A. & Doenhoff, M. (1979). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. III. The failure of primary infections with cercariae of one sex to induce resistance to reinfection. Transactions of the Royal Society of Tropical Medicine and Hygiene 73, 37–41.CrossRefGoogle ScholarPubMed
Coker, C. M. & Lichtenberg, F. (1956). A revised method for isolation of Schistosoma mansoni eggs for biological experimentation. Proceedings of the Society for Experimental Biology and Medicine 92, 780–2.CrossRefGoogle ScholarPubMed
Cheever, A. W. (1968). Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissue. Bulletin of the World Health Organization 39, 328–31.Google Scholar
Dean, D. A., Minard, P., Murrell, K. D. & Vannier, W. E. (1978). Resistance of mice to secondary infection with Schistosoma mansoni. II. Evidence for a correlation between egg deposition and worm elimination. American Journal of Tropical Medicine and Hygiene 27, 957–65.CrossRefGoogle Scholar
Dean, D. A., Minard, P., Stirewalt, M. A., Vannier, W. E. & Murrell, K. D. (1978). Resistance of mice to secondary infection with Schistosoma mansoni. I. Comparison of bisexual and unisexual infections. American Journal of Tropical Medicine and Hygiene 27, 951–6.CrossRefGoogle Scholar
Doenhoff, M., Bickle, Q., Long, E., Bain, J. & McGregor, A. (1978). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. I. Demonstration of resistance to reinfection using a model system that involves perfusion of mice within three weeks of challenge. Journal of Helminthology 52, 173–86.CrossRefGoogle Scholar
Erickson, D. G. & Caldwell, W. L. (1965). Acquired resistance in mice and rats after exposure to gamma-irradiated cercariae. American Journal of Tropical Medicine and Hygiene 14, 566–73.CrossRefGoogle Scholar
Ford, C. E., Hamerton, J. L., Barnes, D. W. H. & Loutit, J. F. (1956). Cytological identification of radiation chimaeras. Nature, London 177, 452–4.CrossRefGoogle ScholarPubMed
Frick, L. P., Ritchie, L. S., Knight, W. B. & Taubr, J. H. (1965). Enhancement of acquired resistance against Schistosoma mansoni in albino mice by intraperitoneal immunizing exposures. Journal of Parasitology 51, 230–4.CrossRefGoogle ScholarPubMed
Holanda, J. C., Pellegrino, J., Gazzinelli, G. & Ramalho-Pinto, F. J. (1976). Infectivity for mice of cercariae, schistosomules and intermediate forms of Schistosoma mansoni obtained in vitro. Revista do Instituto de Medicine Tropical de Sao Paulo 18, 410.Google ScholarPubMed
Hunter, G. W., Crandall, R. B., Zickafoose, D. E. & Purvis, Q. B. (1962). Studies on schistosomiasis XVIII. Some factors affecting resistance to Schistosoma mansoni infections in albino mice. American Journal of Tropical Medicine and Hygiene 11, 17–24.CrossRefGoogle Scholar
Long, E., Doenhoff, M. & Bain, J. (1978). Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse; 2. The time at which resistance to reinfection develops. Journal of Helminthology 52, 187–91.CrossRefGoogle ScholarPubMed
Minard, P., Dean, D. A., Jacobson, R. A., Vannier, W. E. & Murrell, K. D. (1978). Immunization of mice with Cobalt-60 irradiated Schistosoma Mansoni cercariae. American Journal of Tropical Medicine and Hygiene 27, 76–86.CrossRefGoogle ScholarPubMed
Moore, D. V. & Meleney, H. E. (1955). Development of Schistosoma mansoni in the peritoneal cavity of mice. Journal of Parasitology 41, 235.CrossRefGoogle ScholarPubMed
Murrell, K. D., Dean, D. A. & Stafford, E. E. (1975). Resistance to infection with Schistosoma mansoni after immunization with worm extracts or live cercariae: role of cytotoxic antibody in mice and guinea pigs. American Journal of Tropical Medicine and Hygiene 24, 955–61.CrossRefGoogle ScholarPubMed
Olivier, L. J. (1966). Infectivity of Schistosoma mansoni cercariae. American Journal of Tropical Medicine and Hygiene 15, 882–5.CrossRefGoogle ScholarPubMed
Olivier, L. J. & Schneidermann, J. (1953). Acquired resistance to Schistosoma mansoni infection in laboratory animals. American Journal of Tropical Medicine and Hygiene 2, 298–306.CrossRefGoogle ScholarPubMed
Phillips, S. M., Reid, W. A. & Sadun, E. H. (1977). The cellular and humoral response to Schistosoma mansoni infections in inbred rats. II. Mechanisms during reexposure. Cellular Immunology 28, 75.Google Scholar
Radke, M. G. & Sadun, E. H. (1963). Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae. Experimental Parasitology 13, 134–42.CrossRefGoogle Scholar
Sher, A., Mackenzie, P. & Smithers, S. R. (1974). Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosormiasis in the mouse. Journal of Infectious Diseases 130, 626–33.CrossRefGoogle ScholarPubMed
Smithers, S. R. (1960). The isolation of viable schistosome eggs by a digestion technique. Transactions of the Royal Society of Tropical Medicine and Hygiene 54, 68–70.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Stirewalt, M. A. (1953). The influence of previous infection of mice with Schistosoma mansoni on a challenging infection with the homologous parasite. American Journal of Tropical Medicine and Hygiene 2, 867–82.CrossRefGoogle ScholarPubMed
Striebel, H. P. & Sarasin, G. (1975). Immunization experiments with various booster antigens after chemotherapeutic eradication of Schistosoma mansoni in white mice. In Nuclear Techniques in Helminthology Research, pp. 145–157. Vienna: International Atomic Energy Agency.Google Scholar
Taylor, M. G., Amin, M. B. A. & Nelson, G. S. (1969). ‘Parthenogenesis’ in Schistosoma mattheei. Journal of Helminthology 43, 197–206.Google Scholar
Villella, J. B., Gomberg, H. J. & Gould, S. E. (1961). Immunization to Schistosoma mansoni developed from gamma-irradiated cercariae. Science 134, 1073–4.CrossRefGoogle Scholar