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Eosinophilia in Kenyan baboons (Papio anubis) induced by Trichinella spiralis and Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

R. F. Sturrock ,
A. E. Butterworth ,
S. D. Karamsadkar ,
R. Kimani ,
M. Imbuga  and
V. Houba
R. F. Sturrock
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
A. E. Butterworth
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
S. D. Karamsadkar
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
R. Kimani
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
M. Imbuga
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
V. Houba
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
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Extract

High primary doses of Trichinella spiralis administered orally to Kenyan baboons (Papio anubis) induced a marked but unpredictable eosinophilia which started 2–3 weeks after infection and persisted as erratic waves for at least 6 months. Low primary oral doses induced no eosinophilia but a later, high challenge gave an accelerated eosino-philic response, although the peak was lower than in high primary infection. Intravenous injection of infective T. spiralis larvae resulted in a predictable, rapid eosinophilic response which persisted for several weeks. Intravenous injection of a particulate material, Sepharose, gave no oesinophilic response.

Percutaneous Schistosoma mansoni infection of baboons resulted in a two-stage eosinophilic response: an initial rise occurred about ⅔ of the way through the pre-patent period and was followed by a second rise at the onset of patency. After peaking, the eosinophilia waned erratically over the next 3 or 4 weeks.

A strong antibody response, measured by countercurrent imnruno-electrophoresis, was given in oral infections with T. spiralis, but intravenous injections elicited little or no antibody formation. Parasitological evidence indicated no cross-resistance to S. mansoni in baboons injected with T. spiralis 9 days previously. Thus, the intravenous injection of infective T. spiralis larvae appears to be a suitable method of inducing experimentally a non-specific eosinophilia to investigate possible immune mechanisms to S. mansoni in the baboon.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 89 - 100
Copyright
Copyright © Cambridge University Press 1977

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