Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-26T00:58:59.305Z Has data issue: false hasContentIssue false
  • English
  • Français

Eosinophilia in Kenyan baboons (Papio anubis) induced by Trichinella spiralis and Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

R. F. Sturrock ,
A. E. Butterworth ,
S. D. Karamsadkar ,
R. Kimani ,
M. Imbuga  and
V. Houba
R. F. Sturrock
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
A. E. Butterworth
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
S. D. Karamsadkar
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
R. Kimani
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
M. Imbuga
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
V. Houba
Affiliation:
Wellcome Trust Research Labotatories, P.O. Box 43640, Nairobi, Kenya and The World Health Organization Research and Training Centre, Nairobi, Kenya.
Get access Rights & Permissions [Opens in a new window]

Extract

High primary doses of Trichinella spiralis administered orally to Kenyan baboons (Papio anubis) induced a marked but unpredictable eosinophilia which started 2–3 weeks after infection and persisted as erratic waves for at least 6 months. Low primary oral doses induced no eosinophilia but a later, high challenge gave an accelerated eosino-philic response, although the peak was lower than in high primary infection. Intravenous injection of infective T. spiralis larvae resulted in a predictable, rapid eosinophilic response which persisted for several weeks. Intravenous injection of a particulate material, Sepharose, gave no oesinophilic response.

Percutaneous Schistosoma mansoni infection of baboons resulted in a two-stage eosinophilic response: an initial rise occurred about ⅔ of the way through the pre-patent period and was followed by a second rise at the onset of patency. After peaking, the eosinophilia waned erratically over the next 3 or 4 weeks.

A strong antibody response, measured by countercurrent imnruno-electrophoresis, was given in oral infections with T. spiralis, but intravenous injections elicited little or no antibody formation. Parasitological evidence indicated no cross-resistance to S. mansoni in baboons injected with T. spiralis 9 days previously. Thus, the intravenous injection of infective T. spiralis larvae appears to be a suitable method of inducing experimentally a non-specific eosinophilia to investigate possible immune mechanisms to S. mansoni in the baboon.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 89 - 100
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Basten, A., Boyer, M. H. & Beeson, P. B. (1970). Mechanism of eosinophilia. I. Factors affecting the eosinophil response in rats to Trichinella spiralis. Journal of Experimental Medicine 131, 1271–87.CrossRefGoogle ScholarPubMed
Butterworth, A. E., Coombs, R. R. A., Gurner, B. W. & Wilson, A. B. (1976). Receptors for antibody-opsonic adherense on eosinophils of guinea pigs. Internaltional Archives of Allergy and Applied Immunology 51, 368–77.CrossRefGoogle Scholar
Butterworth, A. E., Sturrock, R. F., Houba, V., Mahmoud, A. A. F., Sher, A. & Rees, P. H. (1975). Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature, London 256, 727–9.CrossRefGoogle ScholarPubMed
Clegg, J. A. (1965). In vitro cultivation of Schistosoma mansoni. Experimental Parasitology 16, 133–47.CrossRefGoogle ScholarPubMed
Colley, D. G., Katz, S. P. & Wikel, S. K. (1973). Schistosomiasis: an experimental model for the study of immunopathologic mechanisms which involve eosinophils. Advances in the Biosciences 12, 653–65.Google Scholar
Damian, R. T., Greene, N. D., Meyer, K. F., Cheever, A. C., Hubbard, W. J., Hawers, M. E. & Clark, J. D. (1976). Schistosoma mansoni in baboons. III. The course and characteristics of infection with additional observations on immunity. American Journal of Tropical Medicine and Hygiene 25, 299–306.CrossRefGoogle ScholarPubMed
Fischthal, J. H. (1943). Number of larvae and time required to produce active immunity in rats against Trichinella spiralis. Journal of Parasitology 29, 123–6.CrossRefGoogle Scholar
Gönnert, R. (1955). Studies on schistosomiasis. II. Egg formation in Schistosoma mansoni and the fate of the egg in the host. Zeitschrift für Tropenmedizin und Parasitologie 6, 33–52.Google Scholar
Gould, S. E. (1970). Clinical pathology: diagnostic laboratory procedures. In Trichinosis in Man and Animals (ed. Gould, S. E.), Pp. 190–221. Springfield, USA: Charles C. Thomas.Google Scholar
Houba, V., Koech, D. K., Sturrock, R. F., Butterworth, A. E., Kusel, J. R. & Mahmoud, A. A. F. (1976). Soluble antigens and antibodies in sera from baboons infected with Schistosoma mansoni. Journal of Immunology 117, 705–7.CrossRefGoogle ScholarPubMed
Hummer, R. L. (1967). Preventive medicine practices in baboon colony management. In The Baboon in Medical Research, Vol. 2 (ed. Vagtborg, H.), pp. 51–68. Austin & London: The University of Texas Press.Google Scholar
Kagan, I. G. & Norman, L. G. (1970). The serology of trichinosis. In Trichinosis in Man and Animals (ed. Gould, S. E.), pp. 222–68. Springfield, USA: Charles C. Thomas.Google Scholar
Maass, Z. L. (1933). Ueber Eosinophile in Schweineblut bei trichinose. Zentralblatt für Bacteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene 129, 29–34.Google Scholar
Mahmoud, A. A. F., Warren, K. S. & Perters, P. A. (1975). A role for the eosinophil in acquired resistance to Schistosoma mansoni infections as determined by anti-eosinophil serum. Journal of Experimental Medicine 142, 805–13.CrossRefGoogle Scholar
Nelson, G. S. & Mukundi, J. (1962). The distribution of Trichinella spiralis larvae in the muscles of primates. Wiadomości Parazytologiczne 8, 629–32.Google ScholarPubMed
Nelson, G. S. & Mukundi, J. (1963). A strain of Trichinella spiralis from Kenya of low infectivity to rats and domestic pigs. Journal of Helminthology. 37, 329–38.CrossRefGoogle ScholarPubMed
Schriber, R. A. & Zucker-Franklin, D. (1975). Induction of blood eosinophilia by pulmonary embolization of antigen-coated, particles: the relationship to cell-mediated immunity. Journal of Immunology 114, 1348–53.CrossRefGoogle ScholarPubMed
Snedecor, G. W. & Cochran, W. G. (1967). Statistical Methods (6th ed.). Ames, Iowa, USA: The Iowa State University Press.Google Scholar
Sturrock, R. F., Butterworth, A. E. & Houba, V. (1976). Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of Kenyan strains to different exposures of a local parasite strain. Parasitology 73, 239–52.CrossRefGoogle ScholarPubMed
World Health Organization (1974). The immunology of schistosomiasis. Bulletin of the World Health Organization 51, 553–95.Google Scholar