Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-24T17:46:42.810Z Has data issue: false hasContentIssue false
  • English
  • Français

Eimeria tenella: experimental development of resistance to monensin in the chicken

Published online by Cambridge University Press:  06 April 2009

H. D. Chapman
H. D. Chapman
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
Get access Rights & Permissions [Opens in a new window]

Summary

The development of resistance by the Houghton strain of Eimeria tenella (H) to monensin has been studied by serially passaging the strain in groups of 30 birds, each inoculated with 106 oocysts and given 100 p.p.m. of drug in the food. After 16 passages a line partially resistant to this concentration of monensin was produced. Passage of the line in birds medicated with 200 or 300 p.p.m. of monensin did not result in the acquisition of a greater degree of resistance. A further reduction in sensitivity to 100 p.p.m. monensin was obtained, however, when the line was serially passaged in 15 groups of 6 birds each given 3 × 106 oocysts. Five passages in the absence of monensin resulted in restoration of sensitivity, suggesting that the resistance developed was not stable. The pathogenic effects of the line that had been passaged in chickens given 300 p.p.m. of monensin were less than those of the parent line.

Type
Research Article
Information
Parasitology , Volume 89 , Issue 1 , August 1984 , pp. 9 - 16
Copyright
Copyright © Cambridge University Press 1984

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chapman, H. D. (1976 a). Eimeria tenella in chickens: studies on resistance to the anticoccidial drugs monensin and lasalocid. Veterinary Parasitology 2, 187–96.CrossRefGoogle Scholar
Chapman, H. D. (1976 b). Eimeria tenella: experimental studies on the development of resistance to robenidine. Parasitology 73, 265–73.CrossRefGoogle ScholarPubMed
Chapman, H. D. (1978). Drug resistance in coccidia. In Avian Coccidiosis. Proceedings of the 13th Poultry Science Symposium 14–16th September 1977, (ed. Long, P. L., Boorman, K. N. and Freeman, B. M.), pp. 387–412. British Poultry Science Ltd, Edinburgh.Google Scholar
Chapman, H. D. (1982). The sensitivity of field isolates of Eimeria acervulina type to monensin. Veterinary Parasitology 9, 179–83.Google Scholar
Jeffers, T. K. & Bentley, E. J. (1980). Experimental development of monensin resistance in Eimeria meleagrimitis. Poultry Science 59, 1731–5.Google Scholar
Johnson, J. & Reid, W. M. (1970). Anticoccidial drugs. Lesion scoring techniques in battery and floor pen experiments with chickens. Experimental Parasitology 28, 30–6.Google Scholar
McDougald, L. R. (1981). Anticoccidial drug resistance in the Southeastern United States. Polyether, ionophorous drugs. Avian Diseases 25, 600–9.Google Scholar
McLoughlin, D. K. & Gardiner, J. L. (1968). Drug resistance in Eimeria tenella. VI. The experimental development of an amprolium resistant strain. Journal of Parasitology 54, 582–4.Google Scholar
Shumard, R. F., Callender, M. E. & Reid, W. M. (1970). Monensin a new anticoccidial agent. Vol. 3 Pathology, Fourteenth World Poultry Congress, Madrid, 6–12 September 1970, pp. 421–7.Google Scholar
Smith, C. K. & Galloway, R. B. (1983). Influence of monensin on cation influx and glycolysis of Eimeria tenella sporozoites in vitro. Journal of Parasitology 69, 666–70.CrossRefGoogle ScholarPubMed
Smith, C. K., Galloway, R. B. & White, S. L. (1981). Effect of ionophores on survival, penetration and development of Eimeria tenella sporozoites in vitro. Journal of Parasitology 67, 511–16.CrossRefGoogle ScholarPubMed
Smith, C. K. & Strout, R. G. (1980). The influence of the fatty acid composition of Acholeplasma laidlawii membranes on the growth inhibitory activity of narasin, a polyether ionophorous antibiotic. Biochimica et biophysica acta 600, 585–9.CrossRefGoogle ScholarPubMed
Weppelman, R. M., Battaglia, J. A. & Wang, C. C. (1977). Eimeria tenella: the selection and frequency of drug resistant mutants. Experimental Parasitology 42, 56–66.Google Scholar