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Efficacy of treatment of murine Schistosoma mansoni infections with praziquantel and oxamniquine correlates with infection intensity: role of host antibody

Published online by Cambridge University Press:  06 April 2009

P. G. Fallon ,
J. V. Hamilton  and
M. J. Doenhoff
P. G. Fallon
Affiliation:
School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, UK
J. V. Hamilton
Affiliation:
School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, UK
M. J. Doenhoff
Affiliation:
School of Biological Sciences, University of Wales, Bangor, Gwynedd LL57 2UW, UK
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Summary

The reduction in worm burden obtained by treatment of Schistosoma mansoni with praziquantel and oxamniquine was greater in mice with heavy infections than in relatively lightly infected animals. The reduction in worm burden achieved by each drug correlated with the size of the pre-treatment worm burden (r2 = 0·82 and 0·81 for praziquantel and oxamniquine, respectively). Intensity of infection did not affect the degree of tegumental damage and drug-induced antigen exposure on worms recovered soon after treatment with praziquantel. However, praziquantel-treated worms from mice with heavy infections had significantly more murine antibody attached to the treated-worm surface than worms from praziquantel-treated lightly infected mice. Heavily infected mice had greater levels of circulating anti-worm antibodies than lighter infected mice. The correlation between infection intensity and cure rates achieved by praziquantel and oxamniquine may thus be a reflection of the higher litres of relevant antibody in heavily infected mice mediating death of drug-treated worms.

Keywords

Schistosoma mansonipraziquanteloxamniquineinfection intensitycure rates.
Type
Research Article
Information
Parasitology , Volume 111 , Issue 1 , July 1995 , pp. 59 - 66
Copyright
Copyright © Cambridge University Press 1995

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References

REFERENCES

Abramowicz, M. (1992). Drugs for parasitic diseases. The Medical Letter 34, 17–26.Google Scholar
Brindley, P. J. & Sher, A. (1987). The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response. Journal of Immunology 136, 215–20.Google Scholar
Brindley, P. J. & Sher, A. (1990). Immunological involvement in the efficacy of praziquantel. Experimental Parasitology 71, 245–8.Google Scholar
Brindley, P. J., Strand, M., Norden, A. P. & Sher, A. (1989). Role of host antibody in the chemotherapeutic action of praziquantel against Schistosoma mansoni: identification of target antigens. Molecular and Biochemical Parasitology 34, 99–108.Google Scholar
Delgado, V. S., Suarez, D. P., Cesari, I. M. & Incani, R. N. (1992). Experimental chemotherapy of Schistosoma mansoni with praziquantel and oxamniquine: differential effect of single or combined formulations of drugs on various strains and on both sexes of the parasite. Parasitology Research 78, 648–54.Google Scholar
Doenhoff, M. J., Modha, J. & Lambertucci, J. R. (1988). Anti-schistosome chemotherapy enhanced by antibodies specific for a parasite esterase. Immunology 65, 507–10.Google Scholar
Doenhoff, M. J., Sabah, A. A., Fletcher, C., Webbe, G. & Bain, J. (1987). Evidence for an immune-dependent action of praziquantel on Schistosoma mansoni in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 947–51.CrossRefGoogle ScholarPubMed
Fallon, P. G., Cooper, R. O., Probert, A. J. & Doenhoff, M. J. (1992). Immune-dependent chemotherapy of schistosomiasis. Parasitology 105, S41–S48.CrossRefGoogle ScholarPubMed
Fallon, P. G., Smith, P., Nicholls, T., Modha, J. & Doenhoff, M. J. (1994 a). Praziquantel-induced exposure of Schistosoma mansoni alkaline phosphatase: drug-antibody synergy which acts preferentially against female worms. Parasite Immunology 16, 529–35.Google Scholar
Fallon, P. G., McNeice, C., Probert, A. J. & Doenhoff, M. J. (1994 b). Quantification of praziquantel-induced damage on the surface of adult Schistosoma mansoni worms: estimation of esterase and alkaline phosphatase activity. Parasitology Research 80, 623–5.CrossRefGoogle ScholarPubMed
Giboda, M., Loudova, J., Shonova, O., Bouckova, E., Horacek, J., Numrich, P., Ruppel, A., Vitovec, J., Lukes, S. & Noll, P. (1992). Efficacy of praziquantel in treatment of schistosomiasis in a non-endemic country: a follow-up of parasitological, clinical and immunological parameters. Journal of Hygiene, Epidemiology, Microbiology and Immunology 36, 346–55.Google Scholar
Groll, E. (1984). Praziquantel. Advances in Pharmacology and Chemotherapy 20, 219–35.Google Scholar
Harnett, W. & Kusel, J. R. (1986). Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93, 401–5.Google Scholar
Kohn, A., Lopez-alvarez, M. L. & Katz, N. (1982). Transmission and scanning electron microscopical studies in the tegument of male Schistosoma mansoni after oxamniquine treatment. Annales de Parasitologie Humaine et Comparée 57, 285–91.Google Scholar
Lambertucci, J. R., Modha, J. & Doenhoff, M. J. (1989). Schistosoma mansoni: the therapeutic efficacy of oxamniquine is enhanced by immune serum. Transactions of the Royal Society of Tropical Medicine and Hygiene 83, 362–3.Google Scholar
Lima, S. F., Vieira, L. Q., Harder, A. & Kusel, J. R. (1994). Effects of culture and praziquantel on membrane fluidity parameters of adult S. mansoni. Parasitology 109, 57–64.Google Scholar
McLaren, M. L., Lillywhite, J. E., Dunne, D. W. & Doenhoff, M. J. (1981). Serodiagnosis of human S. mansoni infections: enhanced sensitivity and specificity in ELISA using a fraction containing omega 1 and alpha 1. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 72–9.Google Scholar
Mehlhorn, H., Becker, B., Andrews, P., Thomas, H. & Frenkel, J. K. (1981). In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni: a light and electron microscopic study. Arzneimittel-Forschung 31, 544–54.Google Scholar
Modha, J., Lambertucci, J. R., Doenhoff, M. J. & McLaren, D. J. (1990). Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni infected adult worms exposed to praziquantel and immune serum in vivo. Parasite Immunology 12, 321–34.Google Scholar
Sabah, A. A., Fletcher, C., Webbe, G. & Doenhoff, M. J. (1985). Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell deprived mice. Experimental Parasitology 60, 348–54.CrossRefGoogle ScholarPubMed
Shaw, M. K. & Erasmus, D. A. (1988). S. mansoni: praziquantel-induced changes to the female reproductive system. Experimental Parasitology 65, 31–42.Google Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.Google Scholar
Yue, W., Xiao, S. & Mei, J. (1989). Relationship between the effects of praziquantel on mice and rabbits with different intensities of Schistosoma japonicum infection and humoral immunity levels of the host. Acta Pharmacologica Sinica 10, 476–9.Google ScholarPubMed