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Effects of testosterone on Heterakis spumosa infections in mice

Published online by Cambridge University Press:  06 April 2009

A. Harder ,
F. Wunderlich  and
P. Marinovski
A. Harder
Affiliation:
Institute of Parasitology, Pflanzenschutzzentrum Monheim, Bayer- Werk, Leverkusen
F. Wunderlich
Affiliation:
Division of Parasitology, Institute of Zoology, Heinrich-Heine-Universität, Düsseldorf, Germany
P. Marinovski
Affiliation:
Division of Parasitology, Institute of Zoology, Heinrich-Heine-Universität, Düsseldorf, Germany
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Summary

This study describes the effects of testosterone (Te) on the intestinal nematode Heterakis spumosa in mice. The course of Heterakis infections is apparently under Te-control. At high circulating Te-levels as occurring in intact males, Te-treated females, and Te-treated castrated males, the period of release of Heterakis eggs in mouse faeces is greatly extended and the number of eggs released per unit time is markedly elevated in comparison to low Te-levels, as found in untreated females and castrated male mice. Also, the onset of the patent period occurs earlier in Te-treated mice. Testosterone also accelerates development and growth of both female and male worms of Heterakis in mice. Thus, young adult male worms can be observed in the upper colon of Te-treated castrated male mice on day 21 post-infection (p. i.), whereas, at that time, only L4 larvae are present in Te-untreated male castrates. Testosterone also favours the survival of nematodes in hosts. In untreated male castrates, the number of worms present on day 7 p.i. (L2 larvae) is approximately two thirds higher than that found on day 21 p.i. However, such a reduction in the number of worms does not occur in Te-treated castrated mice during the same period of time. The early phases of the life-cycle of Heterakis, i.e. hatching in the small intestine and final settling of L2 larvae in the upper colon are independent of Te. Also, Te does not affect motility and even slightly reduces the fecundity of adult female worms in vitro. Our data suggest that Te and/or Te-metabolites and/or Te-induced host factor(s) accelerate the development and growth of H. spumosa and favour the survival of Heterakis in the colon of mice.

Keywords

Heterakis spumosaintestinal nematodesgender-dependent infectionssex hormonestestosterone
Type
Research Article
Information
Parasitology , Volume 105 , Issue 2 , October 1992 , pp. 335 - 342
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Alexander, J. & Stimson, W. H. (1988). Sex hormones and the course of parasitic infection. Parasitology Today 4, 189–93.CrossRefGoogle Scholar
Ali, S. R. & Sweatman, G. K. (1966). Effect of age, sex, and hormone treatment of the mouse on the level of infestation by Rhipicephalus sanguineus larvae. Journal of Parasitology 52, 407–12.CrossRefGoogle Scholar
Bhai, J. & Pandey, A. K. (1982). Gonadal hormones in experimental Ancylostoma caninum infections in male Swiss Albino mice. International Journal for Parasitology 12, 589–91.CrossRefGoogle ScholarPubMed
Bone, L. W. & Bottjer, K. P. (1986). Nippostrongylus brasiliensis: Effect of host hormones on helminth ingestion in vivo. International Journal for Parasitology 16, 77–80.CrossRefGoogle ScholarPubMed
Charniga, L., Stewart, G. L., Kramer, G. W. & Stanfield, J. A. (1981). The effects of host sex on enteric response to infection with Trichinella spiralis. Journal of Parasitology 67, 917–22.CrossRefGoogle ScholarPubMed
Dobson, C. (1961 a). Certain aspects of the host–parasite relationship of Nematospiroides dubius (Baylis). I. Resistance of male and female mice to experimental infections. Parasitology 51, 173–9.CrossRefGoogle ScholarPubMed
Dobson, C. (1961 b). Certain aspects of the host–parasite relationship of Nematospiroides dubius (Baylis). II. The effect of sex on experimental infections in the rat (an abnormal host). Parasitology 51, 499–510.CrossRefGoogle ScholarPubMed
Dobson, C. (1966). Certain aspects of the host–parasite relationship of Nematospiroides dubius (Baylis). IV. The effects of the age, sex and species of the host on worm growth. Parasitology 56, 407–16.CrossRefGoogle Scholar
Frayha, G. J., Lawlor, W. K. & Dajani, R. M. (1971). Echinococcus granulosus in Albino mice: effect of host sex and sex hormones on the growth of hydatid cysts. Experimental Parasitology 29, 255–62.CrossRefGoogle ScholarPubMed
Grossman, C. J. & Roselle, G. A. (1986). The control of immune response by endocrine factors and the clinical significance of such regulation. Progress of Clinical and Biochemical Medicine 4, 9–56.CrossRefGoogle Scholar
Haley, A. J. (1958). Sex difference in the resistance of hamsters to infection with the rat nematode, Nippostrongylus muris. Experimental Parasitology 7, 338–48.CrossRefGoogle ScholarPubMed
Katz, F. F. (1962). Differences in Strongyloides ratti worm burdens in male and female rats. Journal of Parasitology 48 (Suppl.), 51.Google Scholar
Kiyota, M., Korenga, M., Nawa, Y. & Kotani, M. (1984). Effect of androgen on the expression of the sex difference in susceptibility to infection with Strongyloides ratti in C57BL/6 mice. Australian Journal of Experimental Biology and Medical Science 62, 607–18.CrossRefGoogle ScholarPubMed
Mankau, S. & Hamilton, R. (1972). The effect of sex and sex hormones on the infection of rats with Trichinella spiralis. Canadian Journal of Zoology 50, 579–602.CrossRefGoogle ScholarPubMed
Mathies, A. W. (1959). Certain aspects of the host–parasite relationship of Aspiculuris tetraptera, a mouse pinworm. II. Sex resistance. Experimental Parasitology 8, 39–45.CrossRefGoogle ScholarPubMed
Miller, T. A. (1965). Influence of age and sex on susceptibility of dogs to primary infection with Ancylostoma caninum. Journal of Parasitology 51, 701–4.CrossRefGoogle ScholarPubMed
Novak, M. (1975). Gonadectomy, sex hormones and the growth of tetrathyridial populations of Mesocestoides corti (Cestoda: Cyclophyllidea) in mice. International Journal for Parasitology 5, 269–74.CrossRefGoogle ScholarPubMed
Rife, S. U., Marquez, M. G., Excalante, A. & Velich, T. (1990). The effect of testosterone on the immune response. 1. Mechanism of action on antibody- forming cells. Immunological Investigations 19, 259–70.CrossRefGoogle ScholarPubMed
Roitt, J., Brostoff, J. & Male, D. (1989). Immunity to protozoa and worms. In Immunology (ed. Roitt, J., Brostoff, J. & Male, D.), pp. 17.1–17.15. London: Gower Medical Publishing.Google Scholar
Sadun, E. H. (1948). Methyl testosterone in the diet of chicks and growth of the nematode Ascaridia galli. Journal of Parasitology 34 (Suppl. 18), 322.Google Scholar
Schuurs, A.H.W.M. & Verheul, H. A. M. (1990). Effects of gender and sex steroids on the immune response. Journal of Steroid Biochemistry 35, 157–72.CrossRefGoogle ScholarPubMed
Smith, P. E. (1953). Life history and host–parasite relations of Heterakis spumosa, a nematode parasite in the colon of the rat. American Journal of Hygiene 57, 194–221.Google ScholarPubMed
Solomon, G. B. (1966). Development of Nippostrongylus brasiliensis in gonadectomized and hormone-treated hamsters. Experimental Parasitology 18, 374–96.CrossRefGoogle ScholarPubMed
Solomon, G. B. & Haley, A. J. (1968). Development of rat and hamster strains of Nippostrongylus brasiliensis in gonadectomized male rats and hamsters. Experimental Parasitology 23, 319–22.CrossRefGoogle Scholar
Stahl, W. (1961). Influences of age and sex on the susceptibility of albino mice to infection with Aspiculuris tetraptera. Journal of Parasitology 47, 939–41.CrossRefGoogle ScholarPubMed
Stewart, G. L., Kramer, G. W., Reddington, J. J. & Hamilton, A. M. (1980). Studies on in vitro larvaposition by adult Trichinella spiralis. Journal of Parasitology 66, 94–9.CrossRefGoogle ScholarPubMed
Sthoeger, Z. M., Chiorazzi, N. & Lahita, R. G. (1988). Regulation of the immune response by sex hormones. I. In vitro effects of estradiol and testosterone on pokeweed mitogen-induced human B cell differentiation. Journal of Immunology 141, 91–8.CrossRefGoogle ScholarPubMed
Stimson, W. H. (1987). Sex steroids, steroid receptors and immunity. In Hormones and Immunity (ed. Berczi, I. & Kovacs, K.), pp. 43–53. Lancaster: MTP Press.Google Scholar
Todd, A. C. & Hollingworth, K. P. (1952). Host sex as a factor in development of Ascaridia galli. Experimental Parasitology 1, 303–4.CrossRefGoogle Scholar
Weinstein, Y. & Berkovich, Z. (1981). Testosterone effects on bone marrow, thymus, and suppressor T cells in the (NZB × NZW) F1 mice: its relevance to autoimmunity. Journal of Immunology 126, 998–1002.CrossRefGoogle Scholar
Wetzel, R. (1951). Verbesserte McMaster Kammer zum Auszählen von Wurmeiern. Tierärztliche Rundschau 11, 209.Google Scholar
Winfield, G. F. (1932). Quantitative experimental studies on the rat nematode Heterakis spumosa, Schneider, 1866. American Journal of Hygiene 17, 168–228.Google Scholar
Wunderlich, F., Mossmann, H., Helwig, M. & Schillinger, G. (1988). Resistance to Plasmodium chabaudi in B10 mice: influence of the H-2 complex and testosterone. Infection and Immunity 56, 2400–6.CrossRefGoogle ScholarPubMed
Wunderlich, F., Marinovski, P., Benten, W. P. M., Schmitt-Wrede, H.-P. & Mossmann, H. (1991). Testosterone and other gonadal factor(s) restrict the efficacy of genes controlling resistance to Plasmodium chabaudi malaria. Parasite Immunology 13, 357–67.CrossRefGoogle ScholarPubMed