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The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice

Published online by Cambridge University Press:  06 April 2009

Kathryn Else  and
D. Wakelin
Kathryn Else
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, University of Nottingham, Nottingham NG1 2RD
D. Wakelin
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, University of Nottingham, Nottingham NG1 2RD
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Summary

Two groups of H-2 congenic strains of mice were compared for their susceptibility to a primary infection with the nematode Trichuris muris. Mice of the BALB genetic background were markedly more resistant than mice of the BIO genetic background, as reflected by the rate of expulsion of T. muris from the large intestine. Within each of the two groups of H-2 congenic strains mice possessing the H-2k haplotype (BALB/k, B10.BR) were more susceptible to infection than mice expressing other haplotypes; B10 background strains expressing H-2b (B10) or H-2q (B10.G) alleles were the most resistant of the four congenic strains studied. Differential resistance was observed within three of the four BIO congenic strains and this is discussed in terms of rate of development of the protective immune response in relation to worm development. The results support the conclusion that both H-2-linked and non-H-2 genes play important roles in controlling the immune response which expels worms from the gut.

Type
Research Article
Information
Parasitology , Volume 96 , Issue 3 , June 1988 , pp. 543 - 550
Copyright
Copyright © Cambridge University Press 1988

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