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The effects of cholinergic and serotoninergic drugs on motility in vitro of Haplometra cylindracea (Trematoda: Digenea)

Published online by Cambridge University Press:  06 April 2009

D. M. McKay ,
D. W. Halton ,
J. M. Allen  and
I. Fairweather
D. M. McKay
Affiliation:
1Department of Biology, The Queen's University, Belfast BT7 1NN, UK
D. W. Halton
Affiliation:
1Department of Biology, The Queen's University, Belfast BT7 1NN, UK
J. M. Allen
Affiliation:
2Biomedical Sciences Research Centre, University of Ulster at Jordanstown, Co. Antrim BT37 0QB, UK
I. Fairweather
Affiliation:
1Department of Biology, The Queen's University, Belfast BT7 1NN, UK
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Summary

The spontaneous activity of the somatic muscle of the amphibian lung fluke, Haplometra cylindracea has been recorded in vitro, using an isometric force transducer system. Normal movement consisted of a continuous series of regular contractions which were maintained for over 4 h. Acetylcholine (ACh) inhibited motility and at a concentration of 1 χ 10–3 M induced a flaccid paralysis. A similar response occurred with the cholinomimetic drugs, carbachol and nicotine, although in these instances the inhibition was less easily reversed by washing with frog Ringer. The inhibitory effect of ACh was blocked by d-tubocurarine but not by atropine.

Keywords

Haplometra cylindracea; trematodedigenetic; motility in vitro; neuromuscular system; cholinergic drugs; aminergic drugs
Type
Research Article
Information
Parasitology , Volume 99 , Issue 2 , October 1989 , pp. 241 - 252
Copyright
Copyright © Cambridge University Press 1989

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