Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T07:22:09.196Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of chloroquine on the infectivity of chloroquine-sensitve and -resisant populations of Plasmodium yoelii nigeriensis to mosquitoes

Published online by Cambridge University Press:  06 April 2009

K. Ichimori ,
C. F. Curtis  and
G. A. T. Targett
K. Ichimori
Affiliation:
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
C. F. Curtis
Affiliation:
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
G. A. T. Targett
Affiliation:
Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
Get access Rights & Permissions [Opens in a new window]

Summary

Subtherapeutic doses of chloroquine have been reported to enhance infectivity of drug-resistant Plasmodium species to their vectors. In this investigation, Plasmodium yoelii nigeriensis N67 strain showed enhanced infectivity to mosquitoes when stimulated by chloroquine. Both sensitive and resistant clones were derived from the N67 strain by dilution, showing that this strain is polymorphic for the resistant trait. A resistant subline was derived by selection under drug pressure from a chloroquine-sensitive clone, but neither the sensitive nor the resistant clones or sublines showed enhancement of infectivity in the presence of chloroquine. This suggests that the enhancement of infectivity shown by the N67 strain is a response to chloroquine stimulation shown only by certain of the genotypes within it, and that this response to chloroquine is not a trait causally connected with the genes coding for chloroquine resistance.

Keywords

Plasmodium yoelii nigeriensiscloneschloroquine resistanceinfectivity to mosquitoesAnopheles stephensi
Type
Research Article
Information
Parasitology , Volume 100 , Issue 3 , June 1990 , pp. 377 - 381
Copyright
Copyright © Cambridge University Press 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Carter, R. (1972). Effect of PABA on chloroquine resistance in Plasmodium berghei yoelii. Nature, London 238, 98–9.CrossRefGoogle ScholarPubMed
Chance, M. L., Momen, H., Warhurst, D. C. & Peters, W. (1978). The chemotherapy of rodent malaria, XXIX. DNA relationships within the subgenus Plasmodium (Vinckeia). Annals of Tropical Medicine and Parasitology 72, 13–22.Google Scholar
Gregory, K. G. (1970). Contributions to the experimental chemotherapy of rodent malaria. Ph.D. thesis, University of Liverpool.Google Scholar
Killick-Kendrick, R. (1974). Parasitic protozoa of the blood of rodents: a revision of Plasmodium berghei. Parasitology 69, 225–37.CrossRefGoogle ScholarPubMed
Killick-Kendrick, R., Shute, G. T. & Lambo, A. O. (1968). Malaria parasites of Thamnomys rutilans (Rodentia, Muridae) in Nigeria. Bulletin of the World Health Organization 38, 822–4.Google ScholarPubMed
Kraft, C. H. & Van Eeden, C. (1968). A Non-Parametric Introduction to Statistics. New York, London: The Macmillan Company, Collier- Macmillan Ltd.Google Scholar
Peters, W., Bafort, J., Ramkaran, A. E., Portus, J. H. & Robinson, B. L. (1970). The chemotherapy of rodent malaria, XI. Cyclically transmitted, chioroquine-resistant variants of the Keyberg 173 stain of Plasmodium berghei. Annals of Tropical Medicine and Parasitology 64, 41–51.CrossRefGoogle Scholar
Peters, W. (1980). Chemotherapy and malaria. In Malaria, Vol. 1 (ed. Kreier, J. P.) pp. 45–283. New York: Academic Press.Google Scholar
Ramkaran, A. E. & Peters, W. (1969). Infectivity of chloroquine resistant Plasmodium berghei to Anopheles stephensi enhanced by chloroquine. Nature, London 223, 635–6.CrossRefGoogle ScholarPubMed
Ramkaran, A. E. (1972). The influence of chemical agents on e transmission of rodent malarias. Ph.D. thesis, University of Liverpool.Google Scholar
Trager, W., Tershakovec, M., Lyandvert, L., Stanley, H., Lanners, N. & Gubert, E. (1981). Clones of the malaria parasite Plasmodium falciparum obtained by microscopic selection: their characterization with regard to knobs, chloroquine sensitivity, and formation of gametocytes. Proceedings of the National Academy of Sciences, USA 78, 6527–30.CrossRefGoogle ScholarPubMed
Thaithong, S., Beale, G. H., Fenton, B., Mcbride, J., Rosario, V., Walker, A. & Walliker, D. (1984). Clonal diversity in a single isolate of the malaria parasite Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 242–5.CrossRefGoogle Scholar
Thaithong, S., Beale, G. H. & Chutmongkonkul, M. (1988). Variability in drug susceptibility amongst clones and isolates of Plasmodium falciparum. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 33–6.Google Scholar
Walliker, D., Carter, R. & Sanderson, A. (1975). Genetic studies on Plasmodium chabaudi: recombination between enzyme markers. Parasitology 70, 19–24.CrossRefGoogle ScholarPubMed
Warhurst, D. C. & Killick-Kendrick, R. (1967). Spontaneous resistance to chloroquine in a strain of rodent malaria (Plasmodium berghei yoelii). Nature, London 213, 1048–9.Google Scholar
Wilkinson, N., Noeypatimanondh, S. & Gould, D. J. (1976). Infectivity of Plasmodium falciparum malaria patients for anopheline mosquitoes before and after chloroquine treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene 70, 306–7.CrossRefGoogle ScholarPubMed
William, C. B. (1937). The use of logarithms in the interpretation of certain entomological problems. Annals of Applied Biology 24, 404–14.CrossRefGoogle Scholar