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The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

Published online by Cambridge University Press:  06 April 2009

S. L. Riley  and
J. Chernin
S. L. Riley
Affiliation:
School of Biological Sciences, University of Portsmouth, King Henry Building, Portsmouth PO1 2DY, UK
J. Chernin
Affiliation:
School of Biological Sciences, University of Portsmouth, King Henry Building, Portsmouth PO1 2DY, UK
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Summary

Three strains of male and female mice, CFLP, BALB/c and CBA/ca, were infected i.p. with the tetrathyridia of Mesocestoides corti and examined in groups of 5 at 0, 7, 14, 21, 28 and 42 days post-infection. At post-mortem the numbers of parasites both loose in the peritoneal cavity and in the liver tissue were counted, the livers weighed fresh and sections of liver stained to examine the inflammatory response, encapsulation of the tetrathyridia and for eosinophils, neutrophils, mast cells and plasma cells. BALB/c mice had significantly more parasites loose in the peritoneal cavity than CFLP and CBA/ca mice. Infected livers of all three strains were significantly heavier than control livers; the heaviest livers were those of the CFLP followed by the CBA/ca mice which also showed the greatest rate of weight increase. The tetrathyridia from the peritoneal cavities of the CBA/ca and CFLP mice were covered with a ‘mucilage-like’ substance. Tetrathyridia within the host capsules of the CBA/ca mice contained host cells. There was no strain difference with regard to numbers of tetrathyridia in the liver but male mice harboured significantly more parasites than females. Differences in the numbers of cell types within the liver were detected between the strains but no one strain showed any consistent pattern. There was an overall increase in total white blood counts as well as an increase in the number of eosinophils, monocytes, neutrophils and lymphocytes during the course of the infection.

Keywords

Mesocestoides cortitetrathyridiahistopathologyliverleucocytes
Type
Research Article
Information
Parasitology , Volume 109 , Issue 3 , September 1994 , pp. 291 - 297
Copyright
Copyright © Cambridge University Press 1994

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