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The effect of the expulsion phase of Trichinella spiralis on Hymenolepis diminuta infection in rats

Published online by Cambridge University Press:  06 April 2009

P. R. Christie ,
D. Wakelin  and
M. M. Wilson
P. R. Christie
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
M. M. Wilson
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
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Summary

The effect of the intestinal changes brought about by the expulsion of Trichinella spiralis in rats was studied in relation to the growth and survival of a concurrent infection with Hymenolepis diminuta, a cestode not normally rejected by the rat in low-level infections. Growth of H. diminuta was stunted in rats given T. spiralis just before, or after, infection with H. diminuta, the stunting being more pronounced when the cestode was given closer to the period of inflammation. There was no loss of the cestode from dual-infected rats and no evidence for destrobilation was found. Lower T. spiralis burdens had a correspondingly weaker effect on growth of H. diminuta, and stunting was abolished by administration of the anti-inflammatory drug cortisone acetate. It is concluded that the stunting of H. diminuta is probably due to the non-specific inflammatory component of the rat's response to T. spiralis infection.

Type
Research Article
Information
Parasitology , Volume 78 , Issue 3 , June 1979 , pp. 323 - 330
Copyright
Copyright © Cambridge University Press 1979

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References

REFERENCES

Andreassen, J., Hindsbo, O. & Hesselberg, C. A. (1974). Immunity to Hymenolepis diminuta in rats: destrobilation and expulsion in primary infections, its suppression by cortisone treatment and increased resistance to secondary infections. Proceedings of the 3rd International Congress of Parasitology, Munich, 2, 1056–7.Google Scholar
Behnke, J. M., Bland, P. W. & Wakelin, D. (1977). Effect of the expulsion phase of Trichinella spiralis on Hymenolepis diminuta in mice. Parasitology 75, 79–88.Google Scholar
Braåten, T. & Hopkins, C. A. (1969). The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation. Parasitology 59, 891–905.Google Scholar
Bruce, R. G. & Wakelin, D. (1977). Immunological interaction between Trichinella spiralis and Trichuris muris in the intestine of the mouse. Parasitology 74, 163–73.CrossRefGoogle Scholar
Castro, G. A. (1976). Spatial and temporal integration of host responses to intestinal stages of Trichinella spiralis. In Biochemistry of Parasites and Host-Parasite Relationships (ed. van den Bossche, H.), pp. 343–58. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
Chandler, A. C. (1939). The effects of number and age of worms on development of primary and secondary infections of Hymenolepis diminuta in rats, and an investigation into the true nature of ‘premunition’ in tapeworm infections. American Journal of Hygiene 29, 105–14.Google Scholar
Chappell, L. H. & Pike, A. W. (1976 a). Loss of Hymenolepis diminuta from the rat. International Journal for Parasitology 6, 333–9.Google Scholar
Chappell, L. H. & Pike, A. W. (1976 b). Interactions between Hymenolepis diminuta and the rat. In Biochemistry of Parasites and Host-Parasite Relationships (ed. van den Bossche, H.), pp. 379–84. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
Dineen, J. K., Gregg, P., Windon, R. G., Donald, A. D. & Kelly, J. P. (1977). The role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes. International Journal for Parasitology 7, 211–15.Google Scholar
Harris, W. G. & Turton, J. A. (1973). Antibody response to tapeworm (Hymenolepis diminuta) in the rat. Nature, London 246, 521–2.Google Scholar
Hesselberg, C. A. & Andreassen, J. (1975). Some influences of population density on Hymenolepis diminuta in rats. Parasitology 71, 517–24.CrossRefGoogle ScholarPubMed
Heyneman, D. (1962). Studies on helminth immunity. II. Influence of Hymenolepis nana (Cestoda: Hymonolepididae) in dual infections with H. diminuta in white mice and rats. Experimental Parasitology 12, 7–18.Google Scholar
Hopkins, C. A., Subramaniam, G. & Stallard, H. (1972). The development of Hymenolepis diminuta in primary and secondary infections in mice. Parasitology 64, 401–12.CrossRefGoogle ScholarPubMed
Howard, R. J., Christie, P. R., Wakelin, D., Wilson, M. M. & Behnke, J. M. (1978). The effect of concurrent infection with Trichinella spiralis on Hymenolepis microstoma in mice. Parasitology 77, 273–9.Google Scholar
Larsh, J. E. Jr (1963). Experimental trichiniasis. Advances in Parasitology 1, 213–86.CrossRefGoogle ScholarPubMed
Larsh, J. E. Jr & Race, G. J. (1975). Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Experimental Parasitology 37, 251–66.Google Scholar
Read, C. P. (1967). Longevity of the tapeworm Hymenolepis diminuta. Journal of Parasitology 53, 1055–6.Google Scholar
Read, C. P. & Rothman, A. H. (1957). The role of carbohydrates in the biology of cestodes. IV. Some effects of host dietary carbohydrate on growth and reproduction of Hymenolepis. Experimental Parasitology 6, 294–305.CrossRefGoogle ScholarPubMed
Roberts, L. S. & Mong, F. N. (1968). Developmental physiology of cestodes. III. Development of Hymenolepis diminuta in superinfections. Journal of Parasitology 54, 55–62.Google Scholar
Saowakotha, S. (1975). The effect of trichinosis on weight gain and food intake of rats fed low and high protein diet. South East Asian Journal of Tropical Medicine and Public Health 6, 247–50.Google Scholar
Wakelin, P. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72, 173–82.Google Scholar