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The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali

Published online by Cambridge University Press:  13 March 2009

M. SACKO ,
P. MAGNUSSEN ,
M. TRAORÉ ,
A. LANDOURÉ ,
A. DOUCOURÉ ,
C. M. REIMERT  and
B. J. VENNERVALD
M. SACKO*
Affiliation:
Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali
P. MAGNUSSEN
Affiliation:
DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 67, DK 1871, Frederiksberg, Denmark
M. TRAORÉ
Affiliation:
Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali Department of Public Health, Faculté de Médecine de Pharmacie et d'Odonto-Stomatologie, Université de Bamako, BP: 1805, Mali
A. LANDOURÉ
Affiliation:
Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali
A. DOUCOURÉ
Affiliation:
Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali
C. M. REIMERT
Affiliation:
DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 67, DK 1871, Frederiksberg, Denmark
B. J. VENNERVALD
Affiliation:
DBL-Centre for Health Research and Development, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 67, DK 1871, Frederiksberg, Denmark
*
*Corresponding author: Moussa Sacko, Institut National de Recherche en Santé Publique (INRSP), B.P. 1771, Bamako, Mali. Tel.: +223 222 92 11. Fax: +223 222 92 11. E-mail: [email protected]
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Summary

The aim of this study was to assess the effect of two doses of 40 mg/kg praziquantel with 2 weeks interval versus a standard single dose of 40 mg/kg on cure rates, egg reduction, intensity of infection, and micro-haematuria in Schistosoma haematobium infections. A randomised controlled intervention study was carried out among school-aged children in two different endemic settings with follow-up at 3, 6 and 18 months following drug administration. Differences in cure rates between the two treatment regimens were not significant. However, in high transmission areas, the double treatment regimen was more effective in egg reduction than single treatment regimen and the difference in egg reduction between the two treatments was significant at 3 months (P<0·005), 6 months (P<0·0001) and 18 months (P<0·003) after treatment. There was a significant difference in the effect of the two treatments on prevalence of micro-haematuria at 18-month follow-up in both Koulikoro (P<0·001) and Selingue (P<0·003). The study shows that although no significant difference could be observed in the overall cure-rates between the two treatment regimens, the effect of double treatment was a significant reduction in infection intensity as well as micro-haematuria which may have a great impact in reducing subtle morbidity.

Keywords

Schistosoma haematobiumhaematuriacure rateegg reduction ratepraziquantelschoolchildrenMali
Type
SECTION 5 TOWARDS FUTURE USE OF PRAZIQUANTEL
Information
Parasitology , Volume 136 , Special Issue 13: Control of schistosomiasis in sub-Saharan Africa , November 2009 , pp. 1851 - 1857
Copyright
Copyright © 2009 Cambridge University Press

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