Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-27T13:52:48.607Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of concurrent infection with Trichinella spiralis on Hymenolepis microstoma in mice

Published online by Cambridge University Press:  06 April 2009

R. J. Howard ,
P. R. Christie ,
D. Wakelin ,
M. M. Wilson  and
J. M. Behnke
R. J. Howard
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
P. R. Christie
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
M. M. Wilson
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
J. M. Behnke
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
Get access Rights & Permissions [Opens in a new window]

Summary

The intestinal changes brought about by rejection of Trichinella spiralis from mice were studied in relation to their effects on a concurrent infection with Hymenolepis microstoma, a cestode not normally rejected from mice. The rejection phase of T. spiralis was associated with a marked stunting of growth of H. microstoma given just before, during, or just after rejection of the nematode. The survival of H. microstoma was affected only when rejection of T. spiralis coincided with the intestinal phase of the cestode: if T. spiralis rejection was timed to occur after the scolex of the cestode had entered the bile duct there was no loss of H. microstoma. It is suggested that the adverse effects on growth and establishment of H. microstoma were due to the non-specific inflammatory component of the host's response to infection with T. spiralis.

Type
Research Article
Information
Parasitology , Volume 77 , Issue 3 , December 1978 , pp. 273 - 279
Copyright
Copyright © Cambridge University Press 1978

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Behnke, J. M., Bland, P. W. & Wakelin, D. (1977). Effect of the expulsion phase of Trichinella Spiralis on Hymenolepis diminuta infections in mice. Parasitology 75, 79–88.CrossRefGoogle ScholarPubMed
Bruce, R. G. & Wakelin, D. (1977). Immunological interactions between Trichinella spiralis and Trichuris muris in the intestine of the mouse. Parasitology 74, 163–73.CrossRefGoogle Scholar
Castro, G. A., Olson, L. T. & Baker, R. D. (1967). Glucose malabsorption and intestinal histopathology in Trichinella spiralis-infected guinea-pigs. Journal of Parasitology 53, 595–612.CrossRefGoogle ScholarPubMed
Dineen, J. K. & Kelly, J. D. (1973). Expulsion of Nippostrongylus brasiliensis from the intestine of rats: the role of a cellular component derived from bone marrow. International Archives of Allergy and Applied Immunology 45, 504–12.CrossRefGoogle ScholarPubMed
Goulson, H. T. & Larsh, J. E. (1964). The effect against Trichinella spiralis of a 72-hour treatment schedule with cadmium oxide in mice given one–three infections. Journal of the Elisha Mitchell Scientific Society 80, 84–90.Google Scholar
Howard, R. J. (1976). The growth of secondary infections of Hymenolepis microstoma in mice: the effect of various primary infection regimes. Parasitology 72, 317–23.CrossRefGoogle ScholarPubMed
Howard, R. J. (1977). Hymenolepis microstoma: a change in susceptibility to resistance with increasing age of the parasite. Parasitology 75, 241–9.CrossRefGoogle ScholarPubMed
Larsh, J. E. (1967). The present understanding of the mechanism of immunity to Trichinella spiralis. The American Journal of Tropical Medicine and Hygiene 16, 123–32.CrossRefGoogle ScholarPubMed
Larsh, J. E. & Race, G. J. (1975). Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Experimental Parasitology 32, 251–66.CrossRefGoogle Scholar
Larsh, J. E., Goulson, H. T. & Van Zandt, P. D. (1962). The control of Trichinella spiralis in mice by cadmium oxide in feed given on an intermittent schedule. Journal of the Elisha Mitchell Scientific Society 94, 262–72.Google Scholar
Love, R. J., Ogilvie, B. M. & McLaren, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology 30, 7–15.Google ScholarPubMed
Lumsden, R. D. & Karin, D. S. (1970). Electron microscopy of peribiliary connective tissues in mice infected with the tapeworm Hymenolepis microstoma. Journal of Parasitology 56, 1171–83.CrossRefGoogle ScholarPubMed
Moss, G. D. (1971). The nature of the immune response of the mouse to the bile duct cestode, Hymenolepis microstoma. Parasitology 62, 285–94.CrossRefGoogle Scholar
Ogilvie, B. M. (1974). Immunity to parasites (Helminths and Arthropods). Progress in Immunology 2, 4, 127–35.Google Scholar
Read, C. P. & Rothman, A. H. (1957 a). The role of carbohydrate in the biology of cestodes. II. The effect of starvation on glycogenesis and glucose consumption in Hymenolepis. Experimental Parasitology 6, 280–7.CrossRefGoogle ScholarPubMed
Read, C. P. & Rothman, A. H. (1957 b). The role of carbohydrates in the biology of cestodes. IV. Some effects of host dietary carbohydrate on growth and reproduction of Hymenolepis. Experimental Parasitology 6, 294–305.CrossRefGoogle ScholarPubMed
Remington, R. D. & Schork, M. A. (1970). Statistics with Applications to the Biological and Health Sciences, pp. 313–15. Englewood Cliffs, N.J.: Prentice–Hall, Incorporated.Google Scholar
Tan, B. D. & Jones, A. W. (1967). Autoelimination by means of X-rays: distinguishing the crowding factor from others in premunition caused by the mouse bile duct cestode, Hymenolepis microstoma. Experimental Parasitology 20, 147–55.CrossRefGoogle ScholarPubMed
Tan, B. D. & Jones, A. W. (1968). Resistance of mice to reinfection with the bile duct cestode Hymenolepis microstoma. Experimental Parasitology 22, 250–5.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976 a). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72, 173–82.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976 b). Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors. Parasitology 72, 307–15.CrossRefGoogle ScholarPubMed