Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-22T12:08:26.594Z Has data issue: false hasContentIssue false

The effect of an interferon inducer on Eimeria maxima in the chicken

Published online by Cambridge University Press:  06 April 2009

P. L. Long*
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, England
B. S. Milne
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, England
*
*Also at Brunel University, London.

Extract

The intraperitoneal inoculation of chickens with 100–170 mg of Statolon, an artificial interferon inducer in mammals, induced the production of a virus interference factor in the serum. Chickens, 3 and 5 weeks old given 40–170 mg Statolon i.p. produced significantly fewer oocysts after infection with E. maxima than untreated chickens.

Only three serum samples (from a large number examined) taken from chickens 1, 4 or 6 days after E. tenella infection or 6 h and 6 days after E. maxima infection showed slight but significant antiviral effects.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Allison, A. C. (1963). In Viruses, nucleic acids and cancer, pp. 462–84. Baltimore: Williams and Wilkins.Google Scholar
De Clerq, E., Wells, R. D. & Merigan, T. C. (1970). Increase in antiviral activity of polynucleotides by thermal activation. Nature 226, 364–6.CrossRefGoogle Scholar
Freshman, M. M., Merigan, T. C., Remington, J. S. & Brownlee, I. E. (1966). In vitro and in vivo antiviral action of an interferon-like substance induced by Toxoplasma gondii. Proceedings of the Society of Experimental Biology and Medicine 123, 862–6.Google Scholar
Horton-Smith, C. & Long, P. L. (1959). The effects of different anticoccidial agents on the intestinal coccidioses of the fowl. Journal of Comparative Pathology and Therapeutics 69, 192207.Google Scholar
Jahiel, R. I., Nussenzweig, R. S., Vanderberg, J. & Vilcek, J. (1968 a). Anti-malarial effect of interferon inducers at different stages of development of Plasmodium berghei in the mouse. Nature 220, 710–11.Google Scholar
Jahiel, R. I., Vilcek, J., Nussenzweig, R. & Vanderberg, J. (1968 b). Interferon inducers protect mice against Plasmodium berghei malaria. Science 161, 802–4.Google Scholar
Kleinschmidt, W. J., Cline, J. C. & Murphy, E. B. (1964). Interferon production induced by Statolon. Proceedings of the National Academy of Sciences of the United States of America 52, 741–4.Google Scholar
Kleinschmidt, W. J. & Murphy, E. B. (1965). Investigations on interferon induced by Statolon. Virology 27, 484–9.CrossRefGoogle ScholarPubMed
Kleinschmidt, W. J., Ellis, L. F., Van Frank, R. M. & Murphy, E. C. (1968). Interferon stimulation by a double stranded RNA of a mycophage in statolon preparations. Nature 220, 167–8.CrossRefGoogle Scholar
Long, P. L. & Rowell, J. G. (1958). Counting oocysts of chicken coccidia. Laboratory Practice 7, 515–19.Google Scholar
Long, P. L. (1969). Observations on the growth of Eimeria tenella in cultured cells from the parasitized chorioallantoic membranes of the developing chick embryo. Parasitology 59, 757–65.CrossRefGoogle ScholarPubMed
Long, P. L. (1970). Some factors affecting the severity of infection with Eimeria tenella in chicken embryos. Parasitology 60, 435–47.Google Scholar
Remington, J. S. & Merigan, T. C. (1968). Interferons: protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Science 161, 804–6.Google Scholar
Rhim, J. S., Huebner, R. J. & Gisin, S. (1969). Effect of Statolon on acute and persistent murine leukemia and sarcoma virus infections. Proceedings of the Society of Experimental Biology and Medicine 130, 181–7.Google Scholar
Rytel, M. W. & Jones, T. C. (1966). Induction of interferon in mice infected with Toxoplasma gondii. Proceedings of the Society of Experimental Biology and Medicine 123, 859–62.CrossRefGoogle ScholarPubMed
Schultz, W. W., Huang, K-Y. & Gordon, F. B. (1968). Role of interferon in experimental mouse malaria. Nature 220, 709–10.Google Scholar
Sreevalson, T. & Lockart, R. Z. (1966). Interference not mediated by interferon. Nature 212, 540.Google Scholar
Strout, R. G., Ouellette, C. A. & Gangi, D. P. (1969). Effect of inoculum size on development of Eimeria tenella in cell cultures. Journal of Parasitology 55, 406–11.Google Scholar
Weinstein, M. J., Waitz, J. A. & Came, P. E. (1970). Induction of resistance to bacterial infections of mice with Poly I, poly C. Nature 226, 170.Google Scholar
Wheelock, F., Caroline, N. L. & Moore, R. D. (1969). Suppression of established Friend virus leukemia by Statolon. Journal of Virology 4, 16.Google Scholar