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Drug screening in cell culture for the detection of anticoccidial activity

Published online by Cambridge University Press:  06 April 2009

John F. Ryley  and
Robert G. Wilson
John F. Ryley
Affiliation:
Imperial Chemical Industries Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, England
Robert G. Wilson
Affiliation:
Imperial Chemical Industries Ltd, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire, England
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Extract

Methods for screening compounds against Eimeria tenella in cell culture and in the chicken are described. An analysis for incidence of anticoccidial activity and host cell toxicity has been made of 11550 compounds screened in vitro, and some correlation of activity in vitro and in vivo has been attempted. The results show that screening compounds in tissue (cell) culture is not a satisfactory or reliable alternative to screening in chickens, although in vitro studies undoubtedly have a part to play in the evaluation of an active drug.

Type
Research Article
Information
Parasitology , Volume 73 , Issue 2 , October 1976 , pp. 137 - 148
Copyright
Copyright © Cambridge University Press 1976

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References

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