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The development of oral vaccines against parasitic diseases utilizing live attenuated Salmonella

Published online by Cambridge University Press:  06 April 2009

S. N. Chatfield ,
M. Roberts ,
G. Dougan ,
C. Hormaeche  and
C. M. A. Khan
S. N. Chatfield*
Affiliation:
Medeva Vaccine Research Unit, Imperial College of Science Technology and Medicine, Exhibition Road, London, SW7 2AY, UK
M. Roberts
Affiliation:
Medeva Vaccine Research Unit, Imperial College of Science Technology and Medicine, Exhibition Road, London, SW7 2AY, UK
G. Dougan
Affiliation:
Department of Biochemistry, Imperial College of Science Technology and Medicine, Exhibition Road, London, SW7 2AY, UK
C. Hormaeche
Affiliation:
Department of Microbiology, The Medical School, University of Newcastle, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK
C. M. A. Khan
Affiliation:
Department of Microbiology, The Medical School, University of Newcastle, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK
*
* Corresponding author.
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Summary

Genetically defined, live attenuated Salmonella vaccines are proving useful both as oral vaccines against salmonellosis and for the development of multivalent vaccines based on the expression of heterologous antigens in such strains. Several candidate attenuated S. typhi strains are at present being evaluated as new single dose oral typhoid vaccines in human volunteers. The emergence of such a vaccine will facilitate the development of multivalent vaccines for humans. Many antigens from different infectious organisms have been expressed in attenuated Salmonella. A focus of this work has been on developing vaccines against parasitic diseases. This review will summarize the efforts that have been made in this area.

Keywords

Live attenuated SalmonellaOral vaccinesSchistosomiasis
Type
Research Article
Information
Parasitology , Volume 110 , Supplement S1: Symposia of the British Society for Parasitology Volume 32:Parasite vaccines , March 1995 , pp. S17 - S24
Copyright
Copyright © Cambridge University Press 1995

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