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Demodex density increases after adalimumab therapy in ankylosing spondylitis: a pilot study

Published online by Cambridge University Press:  18 April 2022

Xuegang Li
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Nelson Siu Kei Lam
Affiliation:
Faculty of Health and Sciences, The University of Adelaide, Adelaide, South Australia, Australia Department of Emergency, Lyell McEwin Hospital, Elizabeth, South Australia, Australia Department of Medicine, Monash University, Clayton, Victoria, Australia
Li Yang
Affiliation:
Department of Dermatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Anqi Liang
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
Xin Xin Long
Affiliation:
Faculty of Health and Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Junli Guo*
Affiliation:
Department of Nephrology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, People's Republic of China
Shuping Zhong*
Affiliation:
Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, People's Republic of China
*
Authors for correspondence: Junli Guo, E-mail: [email protected]; Shuping Zhong, E-mail: [email protected]
Authors for correspondence: Junli Guo, E-mail: [email protected]; Shuping Zhong, E-mail: [email protected]

Abstract

Demodex infestation and density changes remain one of the main challenges in some clinical settings. Tumour necrosis factor-α (TNF-α) inhibitors have been recommended as a first-line treatment for ankylosing spondylitis (AS). However, there have been no studies investigating the impact of TNF-α inhibitor adalimumab on changes in the Demodex density in patients with AS. The aim of this study was to investigate Demodex density changes before and after adalimumab treatment and analyse the relationship between the Demodex density and clinical characteristics in AS. It was found that the Demodex density was positively correlated with age and C-reactive protein levels and the number of Demodex mites could increase after adalimumab treatment in AS.

Type
Research Article
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally to this work.

References

Akilov, OE and Mumcuoglu, KY (2004) Immune response in demodicosis. Journal of the European Academy of Dermatology and Venereology 18, 440444.CrossRefGoogle ScholarPubMed
Annam, V, Yelikar, BR, Inamadar, AC, Palit, A and Arathi, P (2010) Clinicopathological study of itchy folliculitis in HIV-infected patients. Indian Journal of Dermatology, Venereology and Leprology 76, 259262.CrossRefGoogle ScholarPubMed
Arli, C, Ozsan, M, Gurkan, E, Kaya, OA and Kokacya, S (2019) The incidence of Demodex folliculorum in the combination of allergic rhinitis and diabetes mellitus. Iranian Journal of Parasitology 14, 459464.Google ScholarPubMed
Aşkin, U and Seçkin, D (2010) Comparison of the two techniques for measurement of the density of Demodex folliculorum: standardized skin surface biopsy and direct microscopic examination. British Journal of Dermatology 162, 11241126.CrossRefGoogle ScholarPubMed
Baima, B and Sticherling, M (2002) Demodicidosis revisited. Acta Dermato-Venereologica 82, 36.CrossRefGoogle ScholarPubMed
Chang, YS and Huang, YC (2017) Role of Demodex mite infestation in rosacea: a systematic review and meta-analysis. Journal of the American Academy of Dermatology 77, 441447.e6.CrossRefGoogle ScholarPubMed
Cheng, AM, Sheha, H and Tseng, SC (2015) Recent advances on ocular Demodex infestation. Current Opinion in Ophthalmology 20126, 295300.CrossRefGoogle Scholar
Chon, SY and Hassler, AA (2016) Demodex inflammatory eruption due to epidermal growth factor receptor inhibitor therapy. British Journal of Dermatology 174, 686687.CrossRefGoogle ScholarPubMed
Chovatiya, RJ and Colegio, OR (2016) Demodicosis in renal transplant recipients. American Journal of Transplantation 16, 712716.CrossRefGoogle ScholarPubMed
Foley, R, Kelly, P, Gatault, S and Powell, F (2021) Demodex: a skin resident in man and his best friend. Journal of the European Academy of Dermatology and Venereology 35, 6272.CrossRefGoogle ScholarPubMed
Gazi, U, Gureser, AS, Oztekin, A, Karasartova, D, Kosar-Acar, N, Derici, MK, Artuz, F, Mumcuoglu, KY and Taylan-Ozkan, A (2019) Skin-homing T-cell responses associated with Demodex infestation and rosacea. Parasite Immunology 41, e12658.CrossRefGoogle ScholarPubMed
Keskin Kurt, R, Aycan Kaya, O, Karateke, A, Benk Silfeler, D, Soylu Karapınar, O, Neslin Akkoca, A and Hakverdi, AU (2014) Increased density of Demodex folliculorum mites in pregnancies with gestational diabetes. Medical Principles and Practice 23, 369372.CrossRefGoogle ScholarPubMed
Lacey, N, Russell-Hallinan, A, Zouboulis, CC and Powell, FC (2018) Demodex mites modulate sebocyte immune reaction: possible role in the pathogenesis of rosacea. British Journal of Dermatology 179, 420430.Google ScholarPubMed
Liu, Q, Arseculeratne, C, Liu, Z, Whitmire, J, Grusby, MJ, Finkelman, FD, Darling, TN, Cheever, AW, Swearengen, J, Urban, JF and Gause, WC (2004) Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infection and Immunity 72, 37063715.CrossRefGoogle ScholarPubMed
Sędzikowska, A, Osęka, M and Skopiński, P (2018) The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection. Archives of Medical Science 14, 353356.CrossRefGoogle ScholarPubMed
Thoemmes, MS, Fergus, DJ, Urban, J, Trautwein, M and Dunn, RR (2014) Ubiquity and diversity of human-associated Demodex mites. PLoS ONE 9, e106265.CrossRefGoogle ScholarPubMed
Toka Özer, T, Akyürek, Ö and Durmaz, S (2020) Association between Demodex folliculorum and metabolic syndrome. Journal of Cosmetic Dermatology 19, 31453149.CrossRefGoogle ScholarPubMed
van der Linden, S, Valkenburg, HA and Cats, A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis and Rheumatism 27, 361368.CrossRefGoogle ScholarPubMed
Ward, MW, Deodhar, A, Gensler, LS, Dubreuil, M, Yu, D, Khan, MA, Haroon, N, Borenstein, D, Wang, R, Biehl, A, Fang, MA, Louie, G, Majithia, V, Ng, B, Bigham, R, Pianin, M, Shah, AA, Sullivan, N, Turgunbaev, M, Oristaglio, J, Turner, A, Maksymowych, WP and Caplan, L (2019) 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis. Arthritis Care and Research (Hoboken) 71, 12851299.CrossRefGoogle ScholarPubMed
Yamaoka, T, Murota, H, Tani, M and Katayama, I (2014) Severe rosacea with prominent Demodex folliculorum in a patient with HIV. Journal of Dermatology 41, 195196.CrossRefGoogle Scholar