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Cyclosporin A: antiparasite drug, modulator of the host-parasite relationship and immunosuppressant

Published online by Cambridge University Press:  06 April 2009

L. H. Chappell  and
J. M. Wastling
L. H. Chappell
Affiliation:
Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB9 2TN, Scotland
J. M. Wastling
Affiliation:
Moredun Research Institute, 408 Gilmerton Road, Edinburgh, EH17 7JH, Scotland
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Summary

Cyclosporin A (CsA), a cyclic undecapeptide with powerful properties of immunosuppression, acts on parasitic infections in laboratory animals in various ways. The outcome of drug administration in vivo varies with timing of treatment relative to infection, route of administration, dose and number of treatments applied. CsA is clearly antiparasitic against malaria, schistosomes, adult tapeworms, metacestodes and filarial nematodes. By contrast, it acts as an immunomodulator against trypanosomes and Giardia, by exacerbating infection; in the case ofLeishmania spp. the drug acts variously. In some other infections CsA acts both as an antiparasite drug and as an immunosuppressant (Toxoplasma, avian coccidiosis and gastrointestinal nematodes).

Type
Research Article
Information
Parasitology , Volume 105 , Issue S1: Chemotherapy and the immune system , January 1992 , pp. S25 - S40
Copyright
Copyright © Cambridge University Press 1992

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