Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T00:44:51.278Z Has data issue: false hasContentIssue false
  • English
  • Français

A comparative account of the effects of betamethasone on mice infected with Plasmodium vinckei chabaudi and Plasmodium berghei yoelii

Published online by Cambridge University Press:  06 April 2009

F. E. G. Cox
F. E. G. Cox
Affiliation:
Department of Zoology, University of London King's College, Strand, London WC2R 2LS
Get access Rights & Permissions [Opens in a new window]

Extract

The malaria parasites, Plasmodium berghei yoelii and P. vinckei chabaudi, run comparable courses of infection in mice. When mice were treated with betamethasone infections with P. v. chabaudi were enhanced while those of P. b. yoelii were depressed. Antibody levels in betamethasone-treated mice infected with either P. b. yoelii or P. v. chabaudi were depressed to similar extents. The differences in parasitaemias in the two different infections are attributed to the suppression of reticulocyte production by betamethasone. P. b. yoelii preferentially invades reticulocytes and the patterns of parasitaemia follow the level of reticulocytes in the blood. P. v. chabaudi has no preference for reticulocytes and the pattern of parasitaemia is influenced by the depressed immunological response of the host.

Type
Research Article
Information
Parasitology , Volume 68 , Issue 1 , February 1974 , pp. 19 - 26
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barker, L. R. & Powers, K. G. (1971). Immunosuppression in rodent malaria. Effect upon recovery and antibody response. American Journal of Tropical Medicine and Hygiene 20, 389–93.CrossRefGoogle ScholarPubMed
Berglund, K. (1956). Studies on factors which condition the effect of cortisone on antibody production. I. The significance of time of hormone administration in the primary haemolysin response. Acta Pathologica et Microbiologica Scandinavica 38, 311–28.Google Scholar
Brown, I. N. (1969). Immunological aspects of malaria infection. Advances in Immunology 11, 267–349.CrossRefGoogle ScholarPubMed
Cantrell, W. & Kendrick, L. P. (1963). Cortisone and antimalarial drug activity against Plasmodium berghei. Journal of Infectious Diseases 113, 144–50.Google Scholar
Claman, H. N., Levine, M. A. & Cohen, J. J. (1971). Differential effects of corticosteroids on co-operating cells in the immune response. In Cell Interactions and Receptor Antibodies in Immune Responses (ed. Mäkelä, O.Cross, A. and Kosunen, T. U.), pp. 333–44. London and New York: Academic Press.Google Scholar
Cox, F. E. G. (1968). The effect of betamethasone on acquired immunity to Plasmodium vinckei in mice. Annals of Tropical Medicine and Parasitology 62, 295–300.Google Scholar
Cox, F. E. G. (1970). Acquired immunity to Plasmodium chabaudi in Swiss TO mice. Annals of Tropical Medicine and Parasitology 64, 309–14.Google Scholar
Fabiani, G. & Orfila, J. (1955). Étude physiologique des surrenales dans le paludisme expérimentale de la souris blanche. Comptes Rendus des Séances de la Société de Biologie 149, 674–7.Google Scholar
Findlay, G. M. & Howard, E. M. (1952). Cortisone and Plasmodium berghei infections in mice. Nature (London) 169, 547.CrossRefGoogle ScholarPubMed
Fulton, J. D. (1954). Cortisone and Plasmodium berghei infections in rodents. Annals of Tropical Medicine and Parasitology 48, 314–17.Google Scholar
Galliard, H., Lapierre, J., Larivière, M. & Berdonneau, R. (1953). Cortisone et hormone corticotrope (ACTH) dans les parasitoses à protistes sanguicoles. Compte Rendu Hebdomadaire des Séances de l'Academie des Sciences 236, 1308–10.Google Scholar
Herms, V., Baumgart, E. & Kretschmar, W. (1968). Der Einfluss der Adrenalektomie und Cortisonbehandlung auf den Verlauf der Malaria (Plasmodium berghei) in NMRI-Mausen. Zeitschrift fur Tropenmedezin und Parasitologie 19, 389–400.Google Scholar
Roberts, O. J. (1954). The effect of cortisone on Plasmodium berghei infections. Parasitology 44, 58–64.CrossRefGoogle ScholarPubMed
Schneider, J. (1953). Cortisone et paludisme action nulle dans éssais sur Pl. berghei, Pl. gallinaceum et Pl. wvivax. Bulletin de la Société de Pathologie Exotique 46, 1016–23.Google Scholar
Singer, I. (1954). The effect of cortisone on infections with Plasmodium berghei. Journal of Infectious Diseases 94, 164–72.Google Scholar
Spira, D. T., Golenser, J., Zuckerman, A. & Neiss, R. (1972). Multiple modes of action of cyclophosphamide on plasmodial infections in rats. Transactions of the Royal Society of Tropical Medicine and Hygiene 66, 921–30.CrossRefGoogle ScholarPubMed
Topley, E., Bruce-Chwatt, L. J. & Dorrell, J. (1970). Haematological study of a rodent malaria model. Journal of Tropical Medicine and Hygiene 73, 1–8.Google Scholar
Voller, A. (1964). Fluorescent antibody methods and their use in malaria research. Bulletin of the World Health Organisation 30, 343–50.Google ScholarPubMed
Young, A. S. & Cox, F. E. G. (1971). The effect of betamethasone on Babesia microti and B. rodhaini infections in rodents. Parasitology 63, 447–53.CrossRefGoogle Scholar