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Circulating antibodies to histolysain, the major cysteine proteinase of Entamoeba histolytica, in amoebic liver abscess patients

Published online by Cambridge University Press:  06 April 2009

L. M. Osorio ,
T. Picóf  and
A. Luaces
L. M. Osorio
Affiliation:
Departamento de Parasitologlía, Instituto de Medicina Tropical ‘Pedro Kouri’ (IPK), Ciudad de la Habana, Cuba
T. Picóf
Affiliation:
Departamento de Parasitologlía, Instituto de Medicina Tropical ‘Pedro Kouri’ (IPK), Ciudad de la Habana, Cuba
A. Luaces
Affiliation:
Departamento de Parasitologlía, Instituto de Medicina Tropical ‘Pedro Kouri’ (IPK), Ciudad de la Habana, Cuba
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Summary

A solid-phase enzyme immunoassay (EIA) was used to detect circulating antibodies to histolysain, the major cysteine proteinase of Entamoeba histolytica. Serum samples from 40 healthy controls, 33 asymptomatic E. histolytica cyst passers and 22 patients with amoebic liver abscess were tested. Antibodies to histolysain were found in 72·7% of cases of amoebic liver abscess, 18·1% of the cyst passers and 2·5% of healthy controls, which suggests that a humoral immune response is induced by histolysain during amoebic liver abscess.

Keywords

histolysainEntamoeba histolyticaantibodiesamoebiasisliver abscessimmunoassay
Type
Research Article
Information
Parasitology , Volume 105 , Issue 2 , October 1992 , pp. 207 - 210
Copyright
Copyright © Cambridge University Press 1992

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