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Biological effects of lithium chloride on the insect trypanosomatid Herpetomonas samuelpessoai
Published online by Cambridge University Press: 06 April 2009
Summary
Effects of lithium chloride on growth, differentiation and respiration of Herpetomonas samuelpessoai, cultivated in a synthetic medium were studied both at 28 and 37 °C. Low concentration of lithium chloride (15 mM) stimulated growth at 37 °C. In addition, the protozoon tolerated high concentrations (60–150 mM) of the salt at both incubation temperatures. In general, 15 mM lithium chloride increased and 150 mM decreased oxygen uptake when glucose, glutamic acid and proline were used as substrates. However, at 28 °C after incubation for 96 h, the highest concentration increased oxygen uptake in the presence of glucose. Sodium butyrate induced cell differentiation in H. samuelpessoai both at 28 and 37 °C. High concentration (150 mM) of lithium chloride inhibited cell differentiation of H. samuelpessoai induced by both controlled growth conditions and butyrate addition. The results obtained are described in this paper.
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- Copyright © Cambridge University Press 1989
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