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The anti-neoplastic effect of trichinellosis in a syngeneic murine model

Published online by Cambridge University Press:  06 April 2009

Dorothy Pocock  and
Eugene Meerovitch
Dorothy Pocock
Affiliation:
The Institute of Parasitology, McGill University, Macdonald College, Ste. Anne de Bellevue, P. Q, Canada H9X 1C0
Eugene Meerovitch
Affiliation:
The Institute of Parasitology, McGill University, Macdonald College, Ste. Anne de Bellevue, P. Q, Canada H9X 1C0
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Summary

C57B1/6 male mice with chronic trichinellosis, and age-matched uninfected control mice, were inoculated with B16 melanoma cells. Tumour development was inhibited in the infected animals. In the infected tumour-bearing mice, the tumour induction intervals were longer and the tumour size was subsequently smaller than in the control mice. Moreover, when the number of tumour cells in the inoculum was less than that required to produce 100% tumour incidence in the uninfected mice (<1 × 104 cells), significantly more of the mice with an infection of 2 months duration remained tumour-free. These results were significant at the P<0·05 level.

Type
Research Article
Information
Parasitology , Volume 84 , Issue 3 , June 1982 , pp. 463 - 473
Copyright
Copyright © Cambridge University Press 1982

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