Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-28T05:45:29.690Z Has data issue: false hasContentIssue false
  • English
  • Français

Antigenic variation in Babesia rodhaini demonstrated by immunization with irradiated parasites

Published online by Cambridge University Press:  06 April 2009

R. S. Phillips
R. S. Phillips
Affiliation:
National Institute for Medical Research, Mill Hill, London NW7 1AA
Get access Rights & Permissions [Opens in a new window]

Summary

1 Populations of Babesia rodhaini were isolated which were ‘putative’ variants of a reference population.

2. They were shown to have some antigenic dissimilarity to the reference population by comparing the response of rats immunized with irradiated parasites of the reference population, to challenge with either the reference population or with the variant populations. To the homologous challenge the immunized rats were strongly resistant. After a heterologous challenge, however, for the first 3 or 4 days the immunized rats showed no resistance but thereafter rapidly controlled the infection.

3. Five ‘variation’ populations were tested and all were shown to have some antigenic dissimilarity to the reference population. Two variant populations were compared and were not found to be identical with each other. There appeared, however, to be less dissimilarity between them and any one variant and the reference population.

Mrs J. Page and her successor Miss D. Leader, gave technical assistance. I thank my colleagues for helpful criticism of the manuscript.

Type
Research Article
Information
Parasitology , Volume 63 , Issue 2 , October 1971 , pp. 315 - 322
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Awan, M. A. Q. & Clarkson, M. J. (1967). Antigenic variation in Trypanosoma vivax of sheep. Transactions of the Royal Society of Tropical Medicine and Hygiene 61, 13–14.Google Scholar
Barnett, S. F. (1965). The chemotherapy of Babesia bigemina infection in cattle. Research in Veterinary Science 6, 397–415.CrossRefGoogle ScholarPubMed
Brown, K. N. & Brown, I. N. (1965). Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature, London 208, 1286–88.CrossRefGoogle ScholarPubMed
Calver, K. M. (1945). Chemotherapeutic studies on experimental Trypanosoma congolense infections. Ph.D. thesis University of Glasgow. Summarized in Tropical Diseases Bulletin 42, 704–9.Google Scholar
Cunningham, J. (1925). Serological observations on relapsing fever in Madras. Transactions of the Royal Society of Tropical Medicine and Hygiene 29, 11–40.Google Scholar
Curnow, J. A. (1968). In vitro agglutination of bovine erythrocytes infected with Babesia argentina. Nature, London 217, 267–8.CrossRefGoogle ScholarPubMed
Krebs, H. A. & Eggleston, L. V. 1940. The oxidation of pyruvate in pigeon breast muscle. Biochemical Journal 34, 442–9.CrossRefGoogle ScholarPubMed
Lourie, E. M. & O'Connor, B. J. (1937). A study of Trypanosoma rhodesiense relapse strains in vitro. Annals of Tropical Medicine and Parasitology 31, 319–40.CrossRefGoogle Scholar
Lumsden, W. H. R. & Hardy, G. T. C. (1965). Nomenclature of living parasite material. Nature, London 250, 1032.CrossRefGoogle Scholar
Philips, R. S. (1969). Babesia rodhaini infections in the rat after the acute primary parasitaemias. Parasitology 59, 431–56.CrossRefGoogle Scholar
Phillips, R. S. (1970). Resistance of mice and rats to challenge by Babesia rodhaini after inoculation with irradiated red cells infected with B. rodhaini. Nature, London 227, 1255.CrossRefGoogle ScholarPubMed
Philips, R. S. (1971). Immunity of rats and mice following infection with 60Co-irradiated Babesia rodhaini infected red cells. Parasitology 62, 221–31.CrossRefGoogle Scholar
Voller, A. & Rossan, R. N. (1969). Immunological studies with simian malarias. I. Antigenic variants of Plasmodium cynomolgi bastianelli. Transactions of the Royal Society o Tropical Medicine and Hygiene 63, 46–56.CrossRefGoogle Scholar