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Angiogenesis and parasitic helminth-associated neovascularization

Published online by Cambridge University Press:  14 January 2011

ROGER D. DENNIS ,
UWE SCHUBERT  and
CHRISTIAN BAUER
ROGER D. DENNIS*
Affiliation:
Institute for Biochemistry, Justus Liebig University Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
UWE SCHUBERT
Affiliation:
Institute for Biochemistry, Justus Liebig University Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
CHRISTIAN BAUER
Affiliation:
Institute of Parasitology, Justus Liebig University Giessen, Rudolf-Buchheim-Strasse 2, 35392 Giessen, Germany
*
*Corresponding author: Institute for Biochemistry, Justus Liebig University Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Tel: +49 641 99 47460. Fax: +49 641 99 47509. E-mail: [email protected] and [email protected]
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Summary

Successful metazoan parasitism, among many other factors, requires a supply of nutrients and the removal of waste products. There is a prerequisite for a parasite-defined vasculature. The angiogenic mechanism(s) involved presumably depend on the characteristics of the tissue- and vascular system-dwelling, parasitic helminths. Simplistically, 2 possibilities or a combination of both have been considered in this review. The multifactorial induction of parasitic helminth-associated neovascularization could arise through, either a host-, a parasite- or a host-/parasite-dependent, angiogenic switch. Most studies appear to support the first and third hypotheses, but evidence exists for the intrahepatic cestode Echinococcus multilocularis, the free-living nematode Caenorhabditis elegans and the intravascular trematode Schistosoma mansoni for the second inference. In contrast, the nematode anti-coagulant protein NAPc2 from adult Ancylostoma caninum is also an anti-angiogenic factor.

Keywords

angiogenesisangiogenic switchangiogenic growth factorVEGFparasitic helminth-associated neovascularizationCestodaNematodaTrematoda
Type
Review Article
Information
Parasitology , Volume 138 , Issue 4 , April 2011 , pp. 426 - 439
Copyright
Copyright © Cambridge University Press 2011

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