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Anaemia in mice caused by Eperythrozoon coccoides (Schilling, 1928)

Published online by Cambridge University Press:  06 April 2009

June P. Thurston
June P. Thurston
Affiliation:
The Molteno Institute, University of Cambridge
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Extract

Experiments were designed to dissociate the effect of Eperyfhrozoon coccoides on the blood of mice from the effect of splenectomy. Both agents caused a decrease in number of red blood cells which was followed by an increased production of reticulocytes. The anaemic condition caused by the eperythrozoa persisted for more than 230 days after splenectomy, and parasites were seen in fluctuating numbers at intervals throughout this period.

At the height of infection, red blood cells were more fragile than normal in hypotonic saline and the blood clotted more rapidly than normal. No breakdown products of haemoglobin were detected in the urine or serum, and no haemolysins or haemagglutinins were detected in the serum. The white cell count was usually increased after heavy infections, the chief increase being in the number of myelocytes and other immature cells.

Type
Research Article
Information
Parasitology , Volume 44 , Issue 1-2 , May 1954 , pp. 81 - 98
Copyright
Copyright © Cambridge University Press 1954

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References

REFERENCES

Adler, S. (1930 a). The results of splenectomy in white mice as indicated by their reaction to Bartonella muris. Trans. R. Soc. Trop. Med. Hyg. 24, 75.CrossRefGoogle Scholar
Adler, S. (1930 b). The behaviour of Bartonella muris in non-splenectomised mice, and a study of the immune process in mice and rats. Arch. Schiffs-u.Tropenhyg. 34, 440.Google Scholar
Bruynoghe, R. & Vassiliadis, P. C. (1929). L'eperythrozoaire coccoïde. C.R. Soc. Biol, Paris, 100, 1601.Google Scholar
Dinger, J. E. (1929). Näheres über das Eperythrozoon coccoides. Zbl. Bakt. 1 Abt. Orig., 113, 503.Google Scholar
Eliot, C. P. & Ford, W. W. (1930). Eperythrozoon coccoides in mice. Amer. J. Hyg. 12, 667.Google Scholar
McCluskie, J. A. W. & Niven, J. S. F. (1934). The blood changes in rats and mice after splenectomy, with observations on Bartonella muris and Eperythrozoon coccoides. J. Path. Bact. 39, 185.CrossRefGoogle Scholar
Neitz, W. O. (1937). Eperythrozoonosis in sheep. Onderstepoort J. Vet. Sci. 9, 9.Google Scholar
Neitz, W. O. (1940). Eperythrozoonosis in cattle. Onderstepoort J. Vet. Sci. 14, 9.Google Scholar
Ramsden, W. (1928). Laboratory Directions for a Junior Course in Physiological and Clinical Chemistry. Liverpool: C. Tinling and Co., Ltd.Google Scholar
Schilling, V. (1928). Eperythrozoon coccoides eine neue durch Splenektomie aktivierbare Dauerinfektion der weissen Maus. Klin.Wschr. 1853.CrossRefGoogle Scholar
Splitter, E. J. (1950). Eperythrozoon suis, the etiologic agent of Ictero-anaemia or an Anaplasmosis-like disease in swine. Amer. J. Vet. Res. 11, 324.Google ScholarPubMed
Stitt, E. R., Clough, P. W. & Branham, S. E. (1948). Practical Bacteriology, Hematology and Parasitology, 10th. ed.London: H. K. Lewis and Co., Ltd.CrossRefGoogle Scholar
Tyzzer, E. E. (1942). A comparative study of grahamellae, haemobartonellae and eperythrozoa in small mammals. Proc. Amer. Phil. Soc. 85, 359.Google Scholar
Weinman, D. (1935). Les parasites érythrocytaires révélés par la splénectomie: bartonella et epérythrozoon. Paris: Amédée Legrand.Google Scholar
Weinman, D. (1944). Infectious anaemias due to Bartonella and related red cell parasites. Trans. Amer. Phil. Soc. 33, 243.CrossRefGoogle Scholar
Whitby, L. E. H. & Britton, C. J. C. (1935). Disorders of the Blood. London: J. and A. Churchill, Ltd.Google Scholar