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An extended proof of migration routes of immature parasites inside hosts: pathways of Nippostrongylus brasiliensis and Strongyloides ratti in the rat are mutually exclusive

Published online by Cambridge University Press:  06 April 2009

N. R. Tindall  and
P. A. G. Wilson
N. R. Tindall
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
P. A. G. Wilson
Affiliation:
University of Edinburgh, Department of Zoology, West Mains Road, Edinburgh EH9 3JT
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Summary

Rigorous proofs applicable to the routes of migration of Strongyloides ratti and Nippostrongylus brasiliensis skin-penetrating juveniles inside the rat are extended. By applying the inequality principle (Tindall & Wilson, 1988) it was confirmed with a probability of error of I in 1010 that N. brasiliensis larvae applied to the skin passed through the lungs on their way to the intestine. Taking the analysis further, migrating larvae of S. ratti or N. brasiliensis were extracted from the nose or lungs, respectively, of donor rats and transferred to recipients by stomach tube to assay their ability to colonize the intestine. Results showed that (a) changes undergone by each parasite in its proven, specific transit site were essential before larvae could establish in the intestines of recipients, (b) these changes were not completed until larvae had been in the nose or lung for a significant period.

Keywords

migrationproofroutenematodeparasite
Type
Research Article
Information
Parasitology , Volume 100 , Issue 2 , April 1990 , pp. 281 - 288
Copyright
Copyright © Cambridge University Press 1990

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References

Abadie, S. (1963). The life cycle of Strongyloides ratti. Journal of Parasitology 49, 241–8.CrossRefGoogle ScholarPubMed
Bell, R. G., Adams, L. S. & Gerb, J. (1981). Strongyloides ratti: dissociation of the rat's protective immunity into systemic and intestinal components. Experimental Parasitology 52, 386–95.Google Scholar
Dawkins, H. J. S. (1989). Strongyloides ratti infections in rodents: value and limitations as a model of human strongyloidiasis. In Strongyloidiasis, a Major Roundworm Infection of Man (ed. Grove, D. E.), pp. 387–432. London: Taylor & Francis.Google Scholar
Kawanabe, M., Nojima, H. & Uchikawa, R. (1988). Transmammary transmission of Strongyloides ratti. Parasitology Research 75, 50–6.CrossRefGoogle ScholarPubMed
Mimori, T., Korenaga, M.Chowdhury, N. & Tada, I. (1982). Growth and morphological changes of Strongyloides ratti in rats. Japanese Journal of Parasitology 31, 361–8.Google Scholar
Moqbel, R. (1980). Histopathological changes following primary, secondary and repeated infections of rats with Strongyloides ratti, with special reference to tissue eosinophils. Parasite Immunology 2, 11–27.Google Scholar
Murrell, K. D. (1980). Strongyloides ratti: acquired resistance in the rat to preintestinal migrating larvae. Experimental Parasitology 50, 417–25.CrossRefGoogle ScholarPubMed
Nojima, H., Noda, S., Kawanabe, M. & Sato, A. (1987). Larval migration of Strongyloides ratti with reference to esophagus length. Journal of Parasitology 73, 228—30.CrossRefGoogle ScholarPubMed
Spindler, L. A. (1958). The occurrence of intestinal threadworms, Strongyloides ratti, in the tissues of rats, following experimental percutaneous infection. Proceedings of the Helminthological Society of Washington 25, 107–11.Google Scholar
Tada, I., Mimori, T. & Nakai, M. (1979). Migration route of Strongyloides ratti in albino rats. Japanese Journal of Parasitology 28, 219–27.Google Scholar
Tindall, N. R. & Wilson, P. A. G. (1988). Criteria for a proof of migration routes of immature parasites inside hosts exemplified by studies of Strongloides ratti in the rat. Parasitology 96, 551–63.CrossRefGoogle Scholar
Tindall, N. R. & Wilson, P. A. C. (1990). A basis to extend the proof of migration routes of immature parasites inside hosts: estimated time of arrival of Nippostrongylus brasiliensis and Strongyloides ratti in the gut of the rat. Parasitology 100, 275–80Google Scholar
Twohy, D. W. (1955). The early migration and growth of Nippostrongylus muris in the rat. Journal of Parasitology 41, Suppl., Abstract 128.Google Scholar
Twohy, D. W. (1956). The early migration and growth of Nippostrongylus muris in the rat. American Journal of Hygiene 63, 165–85.Google Scholar
Wertheim, C. & Lengy, J. (1965). Growth and development of Strongyloides ratti Sandground 1925, in the albino rat. Journal of Parasitology 51, 636–9.CrossRefGoogle ScholarPubMed
Wilson, P. A. C. (1983). Roundworm juvenile migration in mammals: the pathways of skin-penetrators reconsidered. In Aspects of Parasitology (ed. Meerovitch, E.), pp. 459–85. Montreal: McGill University Institute of Parasitology.Google Scholar
Yokocawa, S. (1922). The development of Heligmosomum muris Yokogawa, a nematode from the intestine of the wild rat. Parasitology 14, 127–66.CrossRefGoogle Scholar